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Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production platform

Broad Institute

“Bill Studier’s development of T7 phage RNA polymerase for use in preparing RNA templates for multiple uses in research labs worldwide has been a truly revolutionary technical advance for the entire field of molecular biology,” said Joan Steitz, the Sterling Professor of Molecular Biophysics and Biochemistry at Yale University.

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What Limits a Genome’s Size?

Codon

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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A quiet revolution in the world of proteomics

DrugBaron

In 2015, Methuselah Health was founded to investigate the role of proteome instability during ageing, and the extent to which the instability of specific proteins might underlie development of age-related diseases – a concept that arose from the ground-breaking work of Professor Miro Radman (which DrugBaron highlighted previously).

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Codon: Notes on Progress #2

Codon

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52
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A clinical genomicist harnesses team-based science to help rare-disease patients

Broad Institute

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. In 2002, when Rehm was building such a lab at Mass General Brigham, she quickly realized how siloed these labs were.

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Empowering women in STEM: Championing change in genetics

Drug Target Review

After joining Regeneron in 2015, Sabin began developing a novel technique that uses an antibody as a matchmaker between a virus and a desired target cell in order to improve the safety and specificity of gene delivery. Sabin earned her PhD in cellular and molecular biology from the University of Pennsylvania.

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The Codon Guide to Synthetic Biology

Codon

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. FEMS Yeast Research (2015).

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