NIH Director's Blog: Drug Development
JANUARY 5, 2016
But before diving into our first “new science” post of 2016, let’s take a quick look back at 2015 and some of its remarkable accomplishments. Four of 2015’s Top 10 featured developments directly benefited from NIH support—including Science’s “Breakthrough of the Year,” the CRISPR/Cas9 gene-editing technique. Protein Cell.
Drug Target Review
SEPTEMBER 4, 2023
5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. 12(11): e0006980. Nilmar, S. and Anabela, C.
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Agency IQ
AUGUST 11, 2023
Given this significance, it’s worth analyzing its chaotic regulatory history, examining the implications of the risk assessment document itself, and projecting how this controversial active substance is likely to be treated by EU regulators going forward. and EU, however, have diverged from this conclusion.
Codon
APRIL 23, 2024
While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. 2 Our microbial engineering efforts include plans for biocontainment.
Drug Discovery World
JULY 15, 2022
The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The sequencing technology relied on could only yield sequences of relatively short DNA fragments, so the assembly of sequences from highly repetitive regions was a huge challenge.
Drug Discovery World
MARCH 6, 2024
They also involve multiple mutations in non-coding regions of DNA – the ‘dark genome’ which makes up around 98% of our DNA. Mutations in the dark genome affect gene regulation rather than coding, exerting a positive or negative impact on the expression of genes that may be related to disease processes.
Drug Target Review
AUGUST 9, 2023
The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.
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