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A Molecular Portrait of ALS and FTD

Drug Target Review

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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Addressing increasingly resistant drugs by infectious agents

Drug Target Review

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. 12(11): e0006980. Nilmar, S. and Anabela, C.

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A quiet revolution in the world of proteomics

DrugBaron

But data is accumulating to suggest it matters a lot: resolving one variant from another – and understanding what drives their relative concentrations – may be just as important in biology as regulation of gene expression. We are about to find out.

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Making Cells Young

Codon

Most cells (excluding T-cells and B cells after V(D)J recombination) in our body contain the same DNA but appear and behave in distinct ways: A neuron looks and acts very differently from a hepatocyte. While DNA is relatively stable , the epigenome is not; it has to orchestrate changes in cell state, cell type, and more.

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The Festival of Genomics and Biodata 2023 Comes to Boston

PLOS: DNA Science

Two compelling talks will be “Long Noncoding RNAs as Key Regulators of Mood in Women,” from Orna Issler at the Neuroscience Institute at NYU Langone, and “Advising the US Congress and Policymakers on Issues Related to Pathogen Genomics, ” from Sarah Harvey, from the US Government Accountability Office.

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Operation Warp Speed for Rare Diseases: Expected Boom in Drug Development and Approval

Advarra

However, recent advancements in the clinical use of recombinant DNA (rDNA) technology creates opportunities for changing this calculation and addressing a great, unmet medical need. “I Many rare diseases, like cystic fibrosis and sickle cell anemia, are monogenic in nature , caused by mutations to single genes.

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Why Nothing Can Grow on Mars*

Codon

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. 2 Our microbial engineering efforts include plans for biocontainment.