PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. But some species control genetic responses another way – via RNA editing. Because the edits are in RNA, and not DNA, they are fleeting.

RNA 52

RNA DNA Science Laboratories 52

Dark Matter Blog

APRIL 4, 2023

Prior to 2015, I had a casual relationship, at best, with targeting RNA. Targeting RNA is a Whole New World Then in 2015, I became smitten and eloped with RNA, setting out to build a company devoted to bringing to bear industrial drug discovery concepts and methods on a new problem of drugging RNA with small molecules.

Small Molecule 52

Small Molecule RNA Fragment Screening DNA 52

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 104

DNA Engineering RNA Small Molecule 104

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

RNA 98

RNA Regulations Disease DNA 98

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Ratcliff, figured this out back in 2015. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. From Davis J.R.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito.

DNA 52

DNA Engineering RNA Therapies 52

PLOS: DNA Science

MARCH 30, 2023

Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA). The agency started tracking it in 2013, and the spread accelerated in 2015. The post The New Fungus Among Us, Candida auris appeared first on DNA Science.

DNA 52

DNA Hospitals Laboratories Virus 52

The Pharma Data

NOVEMBER 22, 2020

The two companies have been in a strategic research collaboration agreement since 2015, focused on using CRISPR Cas-9 to discover new potential treatments. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. Once the DNA has been cut, the cell’s natural repair mechanisms kick in. ” Source link.

DNA 52

DNA Medical Schools RNA Science 52

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 19, 2023

kilograms of CO 2 and 330 liters of water to make one kilogram of bananas, according to a 2015 study from Ecuador. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

kilograms of CO 2 and 330 liters of water to make one kilogram of bananas, according to a 2015 study from Ecuador. In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening.

DNA 52

DNA RNA Engineering Regulations 52