Breaking C-F bonds in drugs
Metabolite Tales Blog
MAY 12, 2023
In 2021, almost one third of FDA approved drugs contained at least one fluorine. This was surprising given that replacement of a phenyl with a pyrimidine and fluorination of aryl or heteroaryl rings are techniques often used to increase metabolic stability. Xiaojing Wang, Minghua Sun, Connie New, Spencer Nam, Wesley P.
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