2015 Metabolic Stability Pharmacokinetics 
Drug Target Review
JUNE 12, 2023
What are the preclinical characteristics of ISM6331, including its efficacy, safety profile, and drug metabolism and pharmacokinetics (DMPK) properties? The system optimised the molecules that were most likely to succeed in terms of potency, metabolic stability, synthetic accessibility, and more.
Molecular Design
MAY 11, 2019
back in 2015 and you may find this review of that seminal contribution to the drug design literature to be informative. Design decisions in lead optimization are typically supported by assays for a range of properties such as solubility, permeability, metabolic stability and off-target activity as well as pharmacokinetic studies.
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