Drug Target Review

JUNE 12, 2023

Leveraging AI-guided structure-based drug design, Insilico’s research and development team generated an impressive portfolio of over 6,000 molecules and identified three highly promising hit series. He is an adjunct professor of artificial intelligence at the Buck Institute for Research on Aging.

Metabolic Stability 92

Metabolic Stability Clinical Trials Small Molecule Pharmacokinetics 92

Molecular Design

MAY 11, 2019

The heavy citation and wide acceptance of Ro5 provided incentives for researchers to publish their own respective analyses of large (usually proprietary) data sets and this has been expressed more succinctly as “Ro5 envy”. back in 2015 and you may find this review of that seminal contribution to the drug design literature to be informative.

Metabolic Stability 52

Metabolic Stability Pharmacokinetics Pharmaceuticals Drugs 52

Metabolite Tales Blog

MAY 12, 2023

This was surprising given that replacement of a phenyl with a pyrimidine and fluorination of aryl or heteroaryl rings are techniques often used to increase metabolic stability. ACS Medicinal Chemistry Letters 2015 6 (8), 925-929, [link] [11] Kinesin Spindle Protein (KSP) Inhibitors. Amaya, Rebecca Durandis, David S. Elizabeth A.

Drugs 52

Drugs Small Molecule Metabolic Stability FDA Approval 52