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Game-changing pan-TEAD inhibitor for solid tumours

Drug Target Review

Leveraging AI-guided structure-based drug design, Insilico’s research and development team generated an impressive portfolio of over 6,000 molecules and identified three highly promising hit series. The novel molecules were further ranked based on their ADME and selectivity profiles.

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Breaking C-F bonds in drugs

Metabolite Tales Blog

In 2022, fewer of the 19 newly FDA approved small molecule drugs contained F atoms (adagrasib, lenacapavir, oteseconazole, vonoprazan), but this was followed by 3 more approvals of F-containing drugs in the first quarter of 2023 alone (pirtobrutinib, omaveloxolone, leniolisib). Amaya, Rebecca Durandis, David S. Bourgeois, James A.

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