Drug Discovery World

JANUARY 3, 2023

In the 13 years since it was first described, DNA-encoded library (DEL) technology has become a firmly established approach to small molecule hit generation in drug discovery. Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell. ACS Comb Sci (2015). Petersen LK, et al. J Am Chem Soc (2021).

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Drug Target Review

OCTOBER 4, 2023

Groundbreaking strategies like proteolysis-targeting chimeric molecules (PROTACs) are also being explored. 6 Combining the effect of payloads with different mechanisms of action – an approach that revolutionised small molecule chemotherapy – also holds the promise of enhanced therapeutic activity for ADCs.

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Dark Matter Blog

JULY 19, 2021

Arrakis has gone through many significant transitions since its founding in 2015. Or should I say back to retirement, as he was comfortably relaxing at home back in 2016 when Jen Petter lured him back into the fray with the siren call of developing a new class of RNA-targeted small-molecule medicines here at Arrakis.

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The Pharma Data

SEPTEMBER 29, 2020

The collaboration has leveraged Sosei’s StaR technology and Structure-based Drug Design (SBDD) capabilities to design oral small molecules that modulate different G protein-coupled receptor (GPCR) targets across multiple disease areas. At the time, Pfizer made a $33m equity investment in Sosei as part of the collaboration agreement.

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Agency IQ

NOVEMBER 10, 2023

BY ALEXANDER GAFFNEY, MS, RAC | NOV 9, 2023 6:35 PM CST Background on CDER’s Office of Pharmaceutical Quality (OPQ) CDER’s Office of Pharmaceutical Quality became operational in January 2015, making it a still relatively recent addition to the agency. However, there’s not much information available regarding the reorganization just yet.

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Dark Matter Blog

JULY 19, 2021

Back in 2015, I felt compelled to set out in a new direction in drug discovery. However, in June I happened to attend the Gordon Research Conference on Chemical Biology and High-throughput Chemistry where I saw a session on small molecules and RNA. I was in my third year as VP of Chemistry for Celgene. This is a thing?

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NIH Director's Blog: Drug Discovery

JANUARY 14, 2016

Very impressive, and just one of the many reasons why the journal Nature Methods recently named cryo-EM its “Method of the Year” for 2015 [2]. Cryo-EM maps showing the contacts between small molecules and proteins can help to explore questions such as why one drug is better than another or why certain drugs fail. Nature Methods.

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The Pharma Data

JULY 15, 2021

Founded in 2015 and based in Pasadena, California, Protomer is engineering next-generation protein therapeutics that can sense molecular activators in the body. About Protomer Technologies Protomer is engineering next-generation protein therapeutics that can sense molecular activators in the body to automatically activate as needed.

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Drug Target Review

JUNE 12, 2023

The current version of Chemistry42 uses over 40 generative models, including generative autoencoders and generative adversarial networks as well as both structure-based and ligand-based drug design to generate and optimise de novo small molecules.

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Drug Target Review

JANUARY 5, 2024

Å resolution) 6 is now being targeted for small molecule inhibitor discovery and development, by exploiting emergent computational tools to identify potential candidate compounds in silico and then test these predicted inhibitors in in vitro biochemical assays. Journal of Biological Chemistry 298(8), 102167 (2022).

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The Premier Consulting Blog

APRIL 25, 2023

In the US, new small molecule drugs are developed under the requirements of Sections 505(b)(1) and 505(b)(2) of the FFDCA. Summary basis of approval (SBA) for Aristada (NDA 207533, 10/5/2015), [link] [accessed 23 March 2023]. ICH Harmonised Guideline S1B(R1): Testing for carcinogenicity of pharmaceuticals.

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The Pharma Data

OCTOBER 25, 2020

Vatiquinone, developed from PTC’s Bio-e platform, is an investigational oral small molecule that inhibits 15-Lipoxygenase, a key enzyme that regulates oxidative stress and inflammation response pathways underpinning many neurological disease pathologies, including epilepsy. 2015; Chevallier et al. Annals of Neurology.2015;

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The Pharma Data

NOVEMBER 29, 2020

” “The emergence of the PROTAC technology represents another breakthrough in the identification of small molecule drugs. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for cancer treatment. 2015, 58 , 1038?1052. Aguilar, A.; Bernard, D.;

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Metabolite Tales Blog

MAY 12, 2023

In 2022, fewer of the 19 newly FDA approved small molecule drugs contained F atoms (adagrasib, lenacapavir, oteseconazole, vonoprazan), but this was followed by 3 more approvals of F-containing drugs in the first quarter of 2023 alone (pirtobrutinib, omaveloxolone, leniolisib). Blackaby, Alastair J. Lyssikatos, Peter W.

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The Pharma Data

NOVEMBER 18, 2021

— Gilead Exercises Options to Arcus’s Anti-TIGIT Program (Domvanalimab and AB308), Etrumadenant (A2a/A2b Adenosine Receptor Antagonist) and Quemliclustat (Small Molecule CD73 Inhibitor) — — Arcus to Receive Option Payments Totaling $725 million — Gilead Lores,Inc. Nasdaq GILD) and Arcus Biosciences,Inc.

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Codon

MARCH 19, 2024

When a somatic cell is reprogrammed into an iPSC, either by using Yamanaka’s method or small molecules that mimic the four proteins, the epigenomes of the reprogrammed cells are effectively “wiped clean” and reverted into a state comparable to that of an embryonic stem cell. Credit: PA Images / Alamy.

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LifeSciVC

APRIL 27, 2023

Fourteen years on, this corporate experiment has gone far beyond the initial idea, and has established an R&D engine more effective than most big pharma R&D groups at producing best-in-class small molecules against targets that matter in human disease biology. Our long-time clinical development lead, Bhaskar Srivastava, an M.D.

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Molecule Blog

AUGUST 13, 2021

This program focuses on testing and developing three of these small molecules as possible interventions in ageing. These molecules target the longevity field with the aim of letting everyone live healthier, happier and longer lives.

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The Pharma Data

OCTOBER 27, 2020

million in 2015. Primmune aims to advance the development of their novel orally-administered, small molecule toll-like receptor 7 agonists as therapeutic-adjuvants for acute viral diseases and cancer. The $71 million funding includes an initial financing of $32.5 In the U.S., Primmune Therapeutics . The company’s $27.4

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Codon

JUNE 11, 2024

Small molecules can randomly transit through the pore and create disruptions, and the polymerase ratchet mechanism is imperfect, occasionally causing DNA to temporarily reverse direction through the pore. In 2015, Oxford Nanopore spun off another company, Metrichor , to provide base-calling algorithms through a web interface.

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The Pharma Data

SEPTEMBER 15, 2020

In a revolution of therapeutic approaches, Trilomer® peptidomimetic binders combine the cell permeability and degradation resistance of small molecules with the large surface area of antibodies, allowing them to target both intracellular and extracellular targets.

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Drug Discovery World

AUGUST 4, 2022

The developability gap for small-molecule candidates is generally minimal because there are numerous analytical technologies available for rapidly and cheaply gathering information to generate highly complete descriptions. Doing this earlier will help minimise costly time delays, or late-stage program failures. Khan, Sheryl Martin Moe.[link]

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The Pharma Data

JANUARY 11, 2021

is a value-oriented investment manager founded in 2015 and based in Singapore. is a publicly-traded biopharmaceutical company founded upon developing novel, small-molecule therapeutics for the treatment of diseases with unmet medical needs with a primary commercial focus on the U.S. About 3D Investment Partners. MediciNova, Inc.

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NIH Director's Blog: Drug Development

JULY 20, 2017

The next major milestone on the therapeutic pathway was the FDA’s approval in 2015 of Orkambi, a drug that combines ivacaftor with lumacaftor, the first “corrector”. That combination therapy was designed to help CF patients with two copies of the F508del mutation.

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The Pharma Data

OCTOBER 14, 2020

Lanifibranor is believed to be the first drug candidate to be granted this status for the treatment of NASH since January 2015. has expanded its product portfolio to include Blueprint, a self-service, scientific visualization and analytics application for small molecule discovery. Dolmatics – U.K.-based based Dotmatics Ltd.

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Codon

MAY 30, 2023

Read Programming inactive RNA-binding small molecules into bioactive degraders. Malaria deaths plummeted between 2010 and 2015, thanks mostly to the billions of dollars in philanthropic funding that were used to purchase bed nets and medicines. Molecular Therapy. Nature Communications. ACS Synthetic Biology. eClinicalMedicine.

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Codon

MAY 30, 2023

Read Programming inactive RNA-binding small molecules into bioactive degraders. Malaria deaths plummeted between 2010 and 2015, thanks mostly to the billions of dollars in philanthropic funding that were used to purchase bed nets and medicines. Molecular Therapy. Nature Communications. ACS Synthetic Biology. eClinicalMedicine.

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NIH Director's Blog: Drug Development

APRIL 7, 2015

After a whirlwind tour of the cutting-edge robotics facility for high throughput screening of small molecules, she joined me and NCATS Director Dr. Chris Austin in announcing that, thanks to an innovative public-private partnership, an experimental drug originally developed to fight cancer is now showing promise against Alzheimer’s disease.

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The Pharma Data

OCTOBER 26, 2020

Abrocitinib is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. 2015:32(6):409-420. Pfizer recently announced results from the fourth trial in the JADE global development program, JADE TEEN. Additional data from other studies in the JADE program will be presented and published in the coming months.

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New Drug Approvals

JULY 10, 2023

Zavegepant is a highly soluble small molecule calcitonin gene related peptide (CGRP) receptor antagonist, with potential analgesic and immunomodulating activities. The clinical trial is expected to complete in September 2020. Migraine is both widespread and disabling. New Haven, CT.

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The Pharma Data

JULY 21, 2021

Pfizer and Biovac have worked together since 2015 on the sterile formulation, fill, finish and distribution of the Prevenar 13 vaccine. To date, Pfizer and BioNTech have shipped more than 1 billion COVID-19 vaccine doses to more than 100 countries or territories in every region of the world.

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Agency IQ

FEBRUARY 23, 2024

Additionally, this approach is generally no longer applicable to new treatments that are more targeted in their effects, such as immunotherapies and targeted small molecule therapies. This workshop built on three prior workshops held by the FDA-AACR, which took place in 2015, 2016 and 2017.

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The Pharma Data

FEBRUARY 4, 2021

Imbruvica was approved as a monotherapy for WM in 2015 and as a combination therapy with rituximab in 2018 based on the iNNOVATE primary analysis. AbbVie and Frontier Medicines, Corp.,

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Agency IQ

DECEMBER 11, 2023

In 2015, the FDA, along with the American Association for Cancer Research (AACR), held a workshop on dose optimization for small molecules. Dose optimization for oncology products has been an issue flagged for improvement even prior to the creation of OCE.

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