Drug Target Review

OCTOBER 4, 2023

Before joining Abzena in 2015, he held multiple positions of increasing responsibility in Biotech including Head of Cellular Immunology at Cantab Pharmaceuticals, Director of Programs at Piramed Pharma, and R&D Director at Immune Targeting systems. 102 , 1–6 (2016). link] Park H-K, et al.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

The Pharma Data

SEPTEMBER 15, 2020

Due to their fully synthetic modular building blocks, affinity optimization and structure-activity relationships (SAR) can be performed much more rapidly than either traditional medicinal chemistry or targeted mutagenesis of biologics.

Targeted Protein Degradation 52

Targeted Protein Degradation Molecular Biology Science Small Molecule 52

Drug Hunter

AUGUST 21, 2023

Putting it All Together: A Complete Campaign Example from Novartis (NIBR) One case study from Novartis that has previously been highlighted in Molecules of the Month is a HAT program targeting the proteosome. 2015 , 58 (6), 2584-2608. Figure 18. A) Progression of a Novartis HAT program from a screening hit to brain-penetrant leads.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206

LifeSciVC

OCTOBER 28, 2024

late 2015, late 2018). During this time, novel science-heavy platforms were “hot” and well-funded: CRISPR, gene therapy, CAR-T, Targeted Protein Degradation, oligo/mRNAs, next gen chemistry, ADCs, Radiopharm, bispecifics… Truly an amazing period, and Atlas started and backed a number of great stories during this period (e.g.,

Licensing 91

Licensing Licensing Marketing Targeted Protein Degradation 91