2016 - Drug Discovery Digest

Deaths from Excessive Alcohol Use in the US, 2016-2021

Common Sense for Drug Policy Blog

MARCH 4, 2024

Deaths from Excessive Alcohol Use in the US, 2016-2021 "From 2016–2017 to 2020–2021, the average annual number of U.S. deaths from excessive alcohol use increased by more than 40,000 (29%), from approximately 138,000 per year (2016–2017) to 178,000 per year (2020–2021). MMWR Morb Mortal Wkly Rep 2024;73:154–161.

US Cocaine Seizure Effectiveness Rate, 2016-2020

Common Sense for Drug Policy Blog

JULY 16, 2023

US Cocaine Seizure Effectiveness Rate, 2016-2020 " Methodology and Limitations "Seizure data are obtained from OFO administrative records and is considered reliable. Available Data and Discussion "Total seizures dropped to 19,000 kilograms in 2019, the lowest in the 2016-2020 period and down 35 percent from the 2016 to 2019 average.

Government

Government Production Drugs

2016 to 2019 Saw Increase in Prepregnancy Obesity in U.S.

The Pharma Data

NOVEMBER 25, 2020

2016 to 2019 Saw Increase in Prepregnancy Obesity in U.S. 25, 2020 — From 2016 to 2019, there was an increase in prepregnancy obesity in the United States, according to a November data brief published by the U.S. percent in 2016 to 29.0 percent in 2016 to 29.0 Professional. WEDNESDAY, Nov. Driscoll, Ph.D.,

Disease

Disease Research

Webinars

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

MORE WEBINARS

Bio-Techne Announces ISO 13485:2016 Certification for the Woburn, MA Manufacturing Facility

The Pharma Data

OCTOBER 14, 2020

15, 2020 /PRNewswire/ — Bio-Techne Corporation (NASDAQ: TECH), a leading provider of proteins, antibodies and cytokines today announced that its Woburn, Massachusetts site received ISO 13485:2016 certification for Medical Device and Quality Management Systems. MINNEAPOLIS , Oct. ” About Bio-Techne Corporation (NASDAQ: TECH).

International

International Therapies Production Science

Pfizer quits Duchenne gene therapy, lays off staff following study setback

BioPharma Drive: Drug Pricing

JULY 30, 2024

The company is letting go of 150 staffers alongside a decision to officially terminate the high-profile program, which was acquired in 2016.

Therapies

Genome-Wide Association Studies (GWAS): A Refreshed Perspective

Broad Institute

NOVEMBER 8, 2024

Genome-Wide Association Studies (GWAS): A Refreshed Perspective By Maria Nemchuk November 8, 2024 Genome-Wide Association Studies (GWAS): A Refreshed Perspective Alisa Manning Massachusetts General Hospital Harvard Medical School Broad Institute Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring (..)

Medical Schools

Medical Schools Hospitals

Sexual Victimization Allegations Reported by Administrators in Adult Correctional Facilities

Common Sense for Drug Policy Blog

NOVEMBER 8, 2024

The number of allegations rose 121% from 2013 to 2016, which was partly attributable to correctional authorities’ continuing response to the 2012 release of the National Standards to Prevent, Detect, and Respond to Prison Rape. dwf_admin Fri, 11/08/2024 - 12:11 Source Emily D.

Cases of Drug-Resistant Gonorrhea Have Tripled in China, Posing a Global Threat

Drugs.com

MARCH 28, 2024

THURSDAY, March 28, 2024 -- A strain of highly antibiotic-resistant gonorrhea first emerged in China in 2016, and cases of this tough-to-treat infection have tripled there in just five years, Chinese researchers report. It's a warning to the rest.

Drugs

Drugs Research

U.S. Deaths Linked to Alcohol Keep Rising, Especially Among Women

Drugs.com

FEBRUARY 29, 2024

Between 2016 and 2021 (the latest numbers available), "the average number of U.S. THURSDAY, Feb. 29, 2024 -- Deaths where alcohol played a key role climbed sharply in recent years, hitting women even harder than men, new government data shows.

Government

Rescue Breathing in Response to Overdose

Common Sense for Drug Policy Blog

OCTOBER 21, 2024

dwf_admin Mon, 10/21/2024 - 22:09 Source New York State Technical Working Group on Resuscitation Training in Naloxone Provision Programs: 2016 Report. New York State, Department of Health, AIDS Institute; 2016:16. 20 This was rated as a strong recommendation based on a weak quality of evidence."

Large Language Models and Biological Foundation Models

Broad Institute

OCTOBER 11, 2024

Large Language Models and Biological Foundation Models By lcopelan@broadinstitute.org October 11, 2024 Large Language Models and Biological Foundation Models Syed Rizvi Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Possible adulticidal drugs for Onchocerca volvulus

Drug Target Review

SEPTEMBER 21, 2023

The findings supported the possibility put forward by Cotton et al (2016) concerning the chance of repurposing these drugs for adulticidal treatment. Possible adulticidal drugs- something to ponder on Cotton et al (2016) made an important discovery when they sequenced the entire genome of O. The research showed that exposing O.

Drugs

Drugs Treatment Disease Research

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

Drugs.com

SEPTEMBER 21, 2023

21, 2023 -- The United States is experiencing an alarming wave of congenital syphilis, and one southern state saw a 1,000% rise in babies born with the infection between 2016 and 2022. THURSDAY, Sept. The number of babies born with the infection in.

You're Far Less Likely to Get an Opioid Now After Surgery

Drugs.com

DECEMBER 11, 2023

doctors had already cut the amount of opioids they gave patients after surgery by 2022 to just a third of the amount given in 2016, new research shows.Much of the. MONDAY, Dec. 11, 2023 -- In response to the ongoing crisis of opioid misuse, U.S.

Doctors

Doctors Research

Antibody Validation for Flow Cytometry

addgene Blog

SEPTEMBER 10, 2024

Antibody validation is to confirm (or refute) that the antibody is selectively detecting the target-of-interest in your assay and sample-of-interest. The approaches available broadly map onto the five pillars of antibody validation (see: Uhlen et al.,

Community Day

Broad Institute

SEPTEMBER 30, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

Drugs.com

AUGUST 23, 2023

23, 2023 -- The number of Americans undergoing gender-affirming surgery is on the rise, new research reveals, almost tripling between 2016 and 2019 alone. WEDNESDAY, Aug. During that period, more than 48,000 patients -- about half of them between 19.

Research

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Standard Dose Naloxone Effective

Common Sense for Drug Policy Blog

OCTOBER 29, 2024

in 2016, the average number of doses of naloxone administered by SSP participants to reverse overdoses did not change significantly, 1.62 doses in 2016. Although the proportion of opioid overdose deaths attributed to fentanyl grew from 3.5% in 2013 to 68.7% doses in 2013 and 1.52

Production

Production Drugs

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

Tensor factorization + single-cell rna-seq

Broad Institute

AUGUST 8, 2024

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA

Single-cell genomics + LLM or OT

Broad Institute

AUGUST 8, 2024

Single-cell genomics + LLM or OT By lcopelan@broadinstitute.org August 8, 2024 Single-cell genomics + LLM or OT David van Dijk Yale University MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

C-ZIPTF: stable tensor factorization for zero-inflated multi-dimensional genomics data

Broad Institute

OCTOBER 27, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

RNA

RNA Research

Auburn University hosts the 60th edition of the Renowned Computational Biophysics Workshop

SCIENMAG: Medicine & Health

AUGUST 18, 2023

For the first time since 2016, the southern USA was home to the “Hands-On Workshop on Computational Biophysics” with Auburn University, for the first […]

Science

Modeling genotype to phenotype: a search for the right variables and the “natural” objects of selection

Broad Institute

OCTOBER 8, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Unemployment and underemployment significant drivers of suicide: Analysis

SCIENMAG: Medicine & Health

JULY 12, 2023

A study examining unemployment and underemployment figures and suicide rates in Australia has found both were significant drivers of suicide mortality between 2004-2016.

Research

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Yiqun Chen MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Tensor factorization (TBD)

Broad Institute

JANUARY 29, 2024

Tensor factorization (TBD) By lcopelan@broadinstitute.org January 29, 2024 Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall (..)

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Lucy Gao University of British Columbia, Department of Statistics MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

Growth in New/Novel Psychoactive Substances

Common Sense for Drug Policy Blog

JUNE 17, 2024

Between 2016 and 2022, typically around 50 new psychoactive substances appeared on the market for the first time each year; this fell to 26 in 2023. In addition, around 400 previously reported new substances are detected on the market each year."

Marketing

Marketing Drugs

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Aparna Nathan Raychaudhuri Lab, Division of Genetics/Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital; Department of Biomedical Informatics, Harvard Medical School MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall (..)

Medical Schools

Medical Schools Hospitals

On fitness models and the modeling of pandemic evolution

Broad Institute

JANUARY 5, 2024

MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Deaths from Excessive Alcohol Use in the US, 2016-2021

US Cocaine Seizure Effectiveness Rate, 2016-2020

2016 to 2019 Saw Increase in Prepregnancy Obesity in U.S.

Webinars

Bio-Techne Announces ISO 13485:2016 Certification for the Woburn, MA Manufacturing Facility

Pfizer quits Duchenne gene therapy, lays off staff following study setback

Genome-Wide Association Studies (GWAS): A Refreshed Perspective

Sexual Victimization Allegations Reported by Administrators in Adult Correctional Facilities

Cases of Drug-Resistant Gonorrhea Have Tripled in China, Posing a Global Threat

U.S. Deaths Linked to Alcohol Keep Rising, Especially Among Women

Rescue Breathing in Response to Overdose

Large Language Models and Biological Foundation Models

Possible adulticidal drugs for Onchocerca volvulus

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

You're Far Less Likely to Get an Opioid Now After Surgery

Antibody Validation for Flow Cytometry

Community Day

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

Lightning Talks

TBD

Standard Dose Naloxone Effective

TBD

TBD

Microbiome

Molecular dynamics

Tensor factorization + single-cell rna-seq

Single-cell genomics + LLM or OT

C-ZIPTF: stable tensor factorization for zero-inflated multi-dimensional genomics data

Auburn University hosts the 60th edition of the Renowned Computational Biophysics Workshop

Modeling genotype to phenotype: a search for the right variables and the “natural” objects of selection

Alpha Missense

Postdoc flash talks

TBD

TBD

Unemployment and underemployment significant drivers of suicide: Analysis

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

Valid hypothesis testing after clustering

Tensor factorization (TBD)

Valid hypothesis testing after clustering

Growth in New/Novel Psychoactive Substances

TBD

On fitness models and the modeling of pandemic evolution

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