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Obstacles and innovations of macrocyclic drug development

Drug Target Review

Journal of Medicinal Chemistry , 59(6):23122327, 2016. Journal of the American College of Cardiology , 81(16):15531564, 2023. Doak BC, Zheng J, Dobritzsch D, Kihlberg J. How beyond rule of 5 drugs and clinical candidates bind to their targets. Yusof I, Segall MD. Considering the impact drug-like properties have on the chance of success.