KIF1A

MARCH 2, 2024

Wendy Chung discusses advances from the Simons Foundation Powering Autism Research for Knowledge (SPARK) Project, which enrolled 275,000 participants with and without autism, between 2016 and 2022. This has created a platform to learn about autism-associated genes, identify risk factors for subgroups, and better inform new interventions.

Laboratories 119

Laboratories Cell Biology Disease Research 119

Drug Target Review

NOVEMBER 1, 2023

2016 Jun 23;59(12):5604–21. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. 2016 Sep;7(1):11248. Frontiers in Medicine. 2018 Jun 13;5. Castagna D, Budd DC, Macdonald SJF, et al. J Med Chem. 2012 Feb 1;40(1):31–6.

Clinical Trials 134

Clinical Trials Small Molecule Trials Disease 134

Drug Target Review

AUGUST 24, 2023

Coordinated integrin activation by actin-dependent force during T-cell migration. 2016 Oct 10;7(1):13119. LFA-1 in T cell migration and differentiation. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. Walling BL, Kim M.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

The Pharma Data

OCTOBER 19, 2020

USA) from the period of 2006 to 2016. in Cell Biology from Utrecht University. Prior to Aduro, Dr. van de Laar held various development and manufacturing positions at MSD (trademark of Merck & Co., Kenilworth, N.J., Dr. van de Laar holds a M.Sc. in Bioprocess Technology from Wageningen University and a Ph.D. About AM-Pharma.

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

Drug Target Review

MAY 21, 2024

I don’t think that it’s harder for women to enter careers in STEM, at least not in the scientific field—cell biology—that I have predominantly worked in. She returned to Cardiff in 2014 for a Research Fellowship at the European Cancer Stem Cell Research Institute.

Doctors 59

Doctors Science Research Cell Biology 59

Elrig

APRIL 29, 2024

Jasmine has a background in neuroscience and genetic manipulation, with early works focused on using a combined structural and molecular biology approach to assess disease-associated proteins implicated in Alzheimer’s disease. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62