Drug Target Review

AUGUST 24, 2023

Coordinated integrin activation by actin-dependent force during T-cell migration. 2016 Oct 10;7(1):13119. LFA-1 in T cell migration and differentiation. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. Walling BL, Kim M.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Codon

SEPTEMBER 22, 2024

Building on years of research into stem cells and reproductive development, 1 the researchers, led by Professor Katsuhiko Hayashi , developed a method to induce male stem cells to lose their Y chromosome and duplicate the X chromosome, thus becoming female. Human and mouse cells also have several differences in gene regulation.

DNA 96

DNA Laboratories Regulations Therapies 96

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52