Molecule Blog

AUGUST 13, 2021

Morten Scheibye-Knudsen earned his MD in 2007 and his DMSc (PhD) in 2016 from the University of Copenhagen. His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.

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FDA Approval DNA Small Molecule FDA 52

The Pharma Data

DECEMBER 13, 2020

In December 2016 , Silmitasertib was granted Orphan Drug Designation by the U.S. TAIPEI and SAN DIEGO , Dec. 13, 2020 /PRNewswire/ — Senhwa Biosciences, Inc. Silmitasertib is safe and well-tolerated in humans. FDA for the treatment of Cholangiocarcinoma.

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Small Molecule FDA Clinical Trials Trials 40

The Pharma Data

JANUARY 21, 2021

In December 2016 , Silmitasertib was granted Orphan Drug Designation by the U.S. TAIPEI and SAN DIEGO , Jan. 21, 2021 /PRNewswire/ — Senhwa Biosciences, Inc. Silmitasertib is safe and well-tolerated in humans. FDA for the treatment of Cholangiocarcinoma.

Trials 40

Trials Treatment Small Molecule Hospitals 40

Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general Transcription factor II Human (TFIIH).

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Production DNA RNA Regulations 62

The Pharma Data

JULY 11, 2021

The complete results were based on data collected between May 2016 and October 2019 and included 109 rollover patients who were originally evaluated in the HELP Study, and 103 eligible non-rollover patients who did not participate in the initial study but had experienced at least one HAE attack within the previous 12 weeks.

Treatment 52

Treatment Pharmacokinetics Disease Production 52

PLOS: DNA Science

APRIL 17, 2025

Findings can explain sets of symptoms and illnesses in other family members, which DNA Science recently covered in A Genetic Crystal Ball: When Newborn Genome Sequencing Findings Explain Illnesses in Relatives. The post Nixing the Newborn Screening Advisory Committee Is Ill-Advised appeared first on DNA Science.

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Therapies Bioethics DNA Organic Chemistry 96

New Drug Approvals

APRIL 18, 2023

significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss [2]. 2016 Mar 21;11(3):e0151765. They are for reference only. In Vivo Mavorixafor (AMD-070) (2 mg/kg, p.o.) MCE has not independently confirmed the accuracy of these methods. Chow LN, et al.

Clinical Trials 52

Clinical Trials Virus Small Molecule Trials 52

Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. Adventure Scientist Stevie Anna Plummer holds water and scat samples collected in 2016 during an expedition to an unexplored peak in the Himalayas.

Hospitals 116

Hospitals Medical Schools International Research 116

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. Lindsay, b. Gordon, J. and Terry, k. Frederik, Z.,

Drugs 111

Drugs RNA DNA Disease 111

Drug Target Review

JULY 24, 2023

In addition, we have concluded that the gene product is an apicpolast RNA polymerase sigma factor because of the localisation of the gene product, ApSIGMA, in the apicoplast interaction with apicoplast promoter DNA sequences, and the activity of an ApSIGMA- E.coli _RpoS chimeric sigma factor protein.

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RNA Regulations Bioinformatics Laboratories 98

New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. and Europe. mmol, 1.00

Small Molecule 62

Small Molecule DNA Disease Trials 62

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Joining Amgen in 2016, Fernando pioneered a protein engineering team and contributed to industry-leading workflows for multi-specific antibodies. Nature Biotechnology 34 , 204-209 (2016).

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Engineering Virus Therapies Immune Response 105

PLOS: DNA Science

MARCH 21, 2024

The history of gene therapy for MLD is compelling – DNA Science covered it for Rare Disease Day in 2021, here. Antonio Regalado told the Price’s story in MIT Technology Review in 2016, and updated it with the gene therapy news. That would enable identification of children before symptoms begin. Yes, the cost is horrifying.

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Therapies Clinical Trials DNA Trials 97

PLOS: DNA Science

MAY 25, 2023

In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence. The duo is designed to correct the mutation, the MAb targeting the siRNA to the gene behind MD1, where it snips out DNA repeats.

Treatment 52

Treatment DNA RNA Clinical Trials 52

Codon

FEBRUARY 13, 2024

Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. Middle and Right) Once a bacteriophage lands on a cell, it injects its DNA through a tube (purple) into the unwilling host.

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Therapies Virus DNA Clinical Trials 133

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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RNA Regulations Disease DNA 98

PLOS: DNA Science

AUGUST 22, 2024

The tale opens at the Hilo Botanical Gardens in 2016. And there the herbicide sat, until in 2016, workers attempting to repackage and seal the material instead caused a leak. ” The explanation continues, and here’s where it ceases to make sense, to anyone who knows anything about DNA, genes, and genomes. BUT WAIT!!!

DNA 68

DNA Virus Organic Chemistry Science 68

Codon

APRIL 19, 2023

In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. in Plant Physiology (2016). has a genome made of DNA. In 2016, the U.S. From Elitzur T.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. in Plant Physiology (2016). has a genome made of DNA. In 2016, the U.S. From Elitzur T.

DNA 52

DNA RNA Engineering Regulations 52

Drug Target Review

JANUARY 22, 2024

Pioneer TFs can recognise their target DNA sequences in compacted heterochromatin and can trigger remodelling of the adjoining chromatin landscape to provide accessibility to nonpioneer TFs. 2016 April [2024 January 15]; 37:76-81. Journal of Biological Chemistry. 2018 September [2024 January 15]; 293(36):13795-804.

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DNA Engineering Hospitals Research 59

The Pharma Data

FEBRUARY 22, 2022

Then, she served on the Board of Directors of Capgemini for two years (2016-2018) before being appointed to her current position as Group CFO. From 2009 to 2016, he led global oncology development at AstraZeneca, delivering TAGRISSO and LYNPARZA, including Senior Vice President, GMD Head of Oncology and Lead, China GMD (2013-2016).

Clinical Trials 52

Clinical Trials DNA Science Clinical Development 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

AUGUST 4, 2020

Accurate monitoring of Epstein-Barr virus DNA levels is critical, as they are associated with a range of life threatening-diseases including cancer in transplant patients. This is the first quantitative in vitro diagnostic test for Epstein-Barr virus (EBV) DNA in the United States. 2016; Apr 21;127(16):2007-17. Source link.

Virus 52

Virus FDA DNA Laboratories 52

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

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Bioinformatics Immune Response DNA Vaccine 105

The Pharma Data

DECEMBER 21, 2020

2016:8;S494-S497. With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers. LUNGevity Foundation. Types of Lung Cancer. Sethi S, et al.

Treatment 52

Treatment Trials Disease FDA 52

Codon

JUNE 18, 2024

By 2016, Shapiro had set up a research laboratory at the California Institute of Technology in Pasadena and began to devote his attention entirely to gas vesicles. By combining DNA from multiple organisms and inserting it into E. An engineer’s mind, however, does not sit idle for long. megaterium.

Engineering 67

Engineering Laboratories International Clinical Trials 67

Agency IQ

APRIL 19, 2024

Due to the high rates of “complete response” seen with new treatment approaches, a 2016 update to the IMWG criteria recognized the need to identify “deeper” responses than those conventionally defined as complete response.

FDA 40

FDA Disease Trials Clinical Trials 40

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

Engineering 86

Engineering Vaccine Production RNA 86

Codon

SEPTEMBER 22, 2024

From there, researchers took the female cells and grew eggs from them using an elaborate protocol they had initially published in 2016. Erasing methyl groups on DNA is necessary for normal egg and sperm development. The most important step seems to be erasing DNA methylation.

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DNA Laboratories Regulations Therapies 114

Codon

JULY 21, 2024

A 2016 study found that rats who were tickled by their experimenters exhibited Freudensprünge, “joy jumps,” and emitted positive vocalizations. In 1959, before DNA sequencing, temperamentally-wild foxes used in the fur trade were bred for tameness. 9 Nor is breeding necessarily slow.

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Research Engineering Disease Science 122

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

DNA 52

DNA Science Doctors Engineering 52

PLOS: DNA Science

MARCH 14, 2024

Biotechnology has solved many problems, from recombinant DNA and monoclonal antibody-derived drugs, to gene therapy and stem cell transplants, to RNA-based vaccines and genetically modified plants that resist diseases and pesticides. Let Them Eat Snake appeared first on DNA Science. And yes, snake meat tastes like chicken.

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DNA RNA Packaging Production 98