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The use of base editing in stem-cell based therapies

Drug Discovery World

Such stocks have already been created using conventional CRISPR-Cas9 approaches; however, cells edited with CRISPR-Cas9 have an increased risk of random insertions and deletions (indels) which are introduced during a cell’s intrinsic DNA repair process following a DNA double strand break (DSB) from Cas9. 1998;282:1145–1147.

Therapies 130
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Scaling Phage Therapy

Codon

Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. Left) A molecular structure of bacteriophage T4, which infects E. The tech for this process already exists.

Therapies 138
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AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. Bioinformatics is all about bringing together different areas of knowledge.

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Codon Digest: Seeing Colors After Gene Therapy

Codon

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here. From Ling B et al.

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Codon Digest: Seeing Colors After Gene Therapy

Codon

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here. From Ling B et al.

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Codon: Notes on Progress #2

Codon

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52
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The Promise of Gas Vesicles

Codon

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By 2016, Shapiro had set up a research laboratory at the California Institute of Technology in Pasadena and began to devote his attention entirely to gas vesicles.