The use of base editing in stem-cell based therapies
Drug Discovery World
JANUARY 23, 2023
Such stocks have already been created using conventional CRISPR-Cas9 approaches; however, cells edited with CRISPR-Cas9 have an increased risk of random insertions and deletions (indels) which are introduced during a cell’s intrinsic DNA repair process following a DNA double strand break (DSB) from Cas9. 1998;282:1145–1147.
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