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Could NfL accelerate drug development for neurodegenerative diseases?

Drug Discovery World

Interest in neurodegeneration amongst the public has increased in recent months due to several high-profile cases including rugby player Doddy Weir, who was diagnosed with motor neurone disease (MND) in 2016, and actor Bruce Willis, who was diagnosed with frontotemporal dementia (FTD) earlier this year.

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Antibody Drug Conjugates: windows of opportunity

Drug Target Review

The drivers behind the demand for ADCs Providing more targeted therapeutic options in the oncology space has underpinned the rapid growth of the ADC market; between 2016 to 2020, the US ADC market grew by 45 percent to a value of nearly $1.5 Petra holds a D.Phil in synthetic organic chemistry and am MBA from Imperial College London.

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Analysis Chemical Thank You PFAS regulation in California (late 2023 edition)

Agency IQ

PFAS regulation in California (late 2023 edition) California consistently maintains its status as both one of the most important economies in the world as well as one of the most regulated states in the United States. In 2019, the state began to significantly ramp up its PFAS regulation and research.

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Article Periodic Thank You USGS estimates at least 45% of U.S. tap water contains PFAS

Agency IQ

These carbon-fluorine bonds are some of the strongest in organic chemistry, meaning that most PFAS readily persist in the environment. Under the framework, new PFAS are expected to be considered persistent, bioaccumulative, and toxic (PBT) chemicals, which invokes another level of regulation for these future PFAS.

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How to Get Drugs Into the Brain

Drug Hunter

The BBB is composed of specialized brain endothelial cells that regulate the distribution of molecules into and out of the brain from the blood. Unlike the endothelial BBB, the blood-cerebrospinal fluid-barrier (BCSFB) is made up of epithelial cells that similarly regulate the distribution of molecules between the blood and CSF.

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