Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. was founded in 2016 to develop safer, non-opioid therapies for acute and chronic pain. South Rampart Pharma, Inc.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. And given that RNA and lipid nanoparticle synthesis is highly efficient compared to typical bioproduction, it’s likely that the company could have scaled to billions of doses.

Engineering 84

Engineering Vaccine Production RNA 84

Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

New Drug Approvals

JANUARY 9, 2024

As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II). In addition to CDK7, other CDKs have been reported to phosphorylate and regulate RNA pol (II) CTD. 13, 261-91, 1997). 1004-1014, 2004). Oct 1 5;24(20):2303-16, 2010; Blazek et al., Konig et al.,

Production 62

Production DNA RNA Regulations 62

Codon

JUNE 26, 2023

In 2016, Belmonte “reported that sick mice lived 30% longer than expected after receiving a cocktail of special reprogramming proteins,” according to the article in MIT Technology Review. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. They’re incredibly versatile. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

In 2016, Belmonte “reported that sick mice lived 30% longer than expected after receiving a cocktail of special reprogramming proteins,” according to the article in MIT Technology Review. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. They’re incredibly versatile. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

MAY 1, 2024

They found that each of the organs they looked at changed with exercise, helping the body to regulate the immune system, respond to stress, and control pathways connected to inflammatory liver disease, heart disease, and tissue injury. The team studied a range of tissues from the animals, such as the heart, brain, and lungs.

RNA 143

RNA Regulations Immune Response Disease 143

Codon

SEPTEMBER 22, 2024

From there, researchers took the female cells and grew eggs from them using an elaborate protocol they had initially published in 2016. Epigenetic CRISPR tools are targeted to a particular DNA sequence using a guide RNA molecule. Human and mouse cells also have several differences in gene regulation. On average, 41.4%

DNA 96

DNA Laboratories Regulations Therapies 96

NIH Director's Blog: Drug Development

JANUARY 5, 2016

But before diving into our first “new science” post of 2016, let’s take a quick look back at 2015 and some of its remarkable accomplishments. This gene-editing system consists of a short segment of RNA that is attached to an enzyme. A new year has arrived, and it’s going to be an amazing one for biomedical research.

Vaccine 52

Vaccine Science Engineering Disease 52

Codon

APRIL 19, 2023

This gene is regulated, in turn, by a small arsenal of other proteins from the MaMADS family. ( In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. Yes, I know.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

This gene is regulated, in turn, by a small arsenal of other proteins from the MaMADS family. ( In 2016, her team demonstrated that, by adding short snippets of DNA or RNA — which can target and “shut down” the MaMADS regulatory proteins — to bananas, it is possible to slow their ripening. Yes, I know.

DNA 52

DNA RNA Engineering Regulations 52

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Gene Expression and Regulation. Link Biological Networks & Mathematics →Network motifs in the transcriptional regulation network of Escherichia coli , by Shen-Orr S.S. Nature (2016).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Gene Expression and Regulation. Link Biological Networks & Mathematics →Network motifs in the transcriptional regulation network of Escherichia coli , by Shen-Orr S.S. Nature (2016).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Drug Target Review

NOVEMBER 27, 2024

Advanced techniques like liquid chromatography tandem mass spectrometry (LC-MS/MS) and Meso Scale Discovery (MSD) provide the kind of comprehensive and reliable data increasingly favoured by regulators, yet many researchers continue to rely exclusively on enzyme-linked immunosorbent assay (ELISA). billion in 2016 and continues to grow.

Drug Development 52

Drug Development Regulations Laboratories FDA 52

Codon

DECEMBER 1, 2024

Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” In 1956, Crick was working on a lecture that would bring together what was then known about the “flow of information” between DNA, RNA, and protein in cells.

RNA 117

RNA DNA Molecular Biology Virus 117