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I've included some photos to break up the text a bit and these are from a 2016 visit to the north of Vietnam. The distinction between Type 1 and and Type 2 behaviors is an important and useful one to make from the perspective of drug discovery scientists who are making decisions as to which screeninghits to take forward.
A) Progression of a Novartis HAT program from a screeninghit to brain-penetrant leads. This program started from an HTS screen of 3M compounds, resulting in a singleton hit (Figure 17). 2016 , 7 (6), 767-775. Figure 18. link] (Pfizer) Wager, T.T.; Verhoest, P.R.; Villalobos, A. Barden, C.J.; Weaver, D.F.
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