Drug Patent Watch

JULY 26, 2022

This chart shows the generic pharmaceutical companies that had the most successful drug patent challenges from 2017 to 2022. Companies that successfully challenge patents on branded drugs are granted six…. The post Most prolific drug patent challengers appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies 98

Pharmaceutical Companies Drugs Pharmaceuticals 98

Drug Discovery Today

NOVEMBER 27, 2019

million cases worldwide in 2017, costing over US$100B per year. Heart failure is a global pandemic with an estimated 64.3 Drug developers currently lack effective humanized models for preclinical testing of targeted drug candidates in heart failure with preserved ejection fraction.

Drug Development 100

Drug Development Drugs 100

Drug Target Review

MARCH 15, 2024

2017 Nov;33(6):1468-1475. Epub 2017 Sep 7. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014. Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic. Biotechnol Prog. doi: 10.1002/btpr.2548. PMID: 28842948. Narayanavari SA, Izsvák Z. Patel T, Ingham C, Fleming J, et al.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

SCIENMAG: Medicine & Health

AUGUST 26, 2023

In 2017, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of Mitotane in the prevention of recurrence in adrenocortical carcinoma.

Therapies 92

Therapies Drugs 92

Drug Target Review

NOVEMBER 1, 2023

He formerly worked at EMBL as a postdoctoral fellow from 2017 to 2020 where he discovered the inhibition of ATX with THC. 2017 Mar 9;60(5):2006–17. 2017 Jan 26;60(2):722–48. Dr Jens Hausmann Jens obtained his PhD from Leiden University for his work at the Netherlands Cancer Institute in Amsterdam, Netherlands. 2018 Jun 13;5.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

NIOSH Science Blog: Drugs

JUNE 7, 2023

2017; WHO, 2017). No matter the country, people with hearing difficulties often take years to seek care. Even when they do, uptake of recommended interventions, particularly hearing aids, is low (Wilson et al., To “raise awareness on how to

International 79

International 79

SCIENMAG: Medicine & Health

AUGUST 26, 2023

Enormous amounts of sediment, or sand and mud, flowed through Houston waterways during Hurricane Harvey in 2017, due in part to modifications made by humans to bayous, rivers and streams over the past century, that could seriously impact future flooding events and be costly to the City of Houston.

Science 89

Science 89

SCIENMAG: Medicine & Health

AUGUST 2, 2023

The researchers, from the University of Cambridge, studied industry data from the UK and 24 other European countries between 1995 and 2017, and found that at low levels of adoption, robots have […]

Research 88

Research 88

FDA Law Blog: Biosimilars

MAY 13, 2024

It was Congress that intervened in 2022, to mandate FDA to issue or revise its 2017 guidance on considerations for the use of RWD and RWE to support regulatory decision-making for devices to clarify its regulatory expectations. This guidance, when finalized, will replace the original version of this document finalized in 2017.

FDA 111

FDA Production Trials Pharmacy 111

SCIENMAG: Medicine & Health

JULY 7, 2023

“In 2017, we reported a new family of 2D transition metal borides as analogues to MXenes and coined a catchy name for them, MBenes,” said paper author Zhimei […] They published their work on July. 6 in Energy Material Advances. Credit: Ya Gao, Beihang University They published their work on July.

Engineering 87

Engineering 87

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

73

73

Science Daily: Pharmacology News

MAY 30, 2023

Some islands saw their population drop to as low as 15 individuals, but conservation efforts by the Federal government restored numbers by 2017. Starting in the 1990s, Island Fox populations began to dwindle due to an outbreak of canine distemper and an increase in attacks by golden eagles.

Government 93

Government 93

Drugs.com

MARCH 11, 2024

MONDAY, March 11, 2024 -- The cost to American families of caring for a child with a mental health condition rose by almost a third between 2017 and 2021, a new report finds, to an average $4,361 per year. Overall, American families spent an.

74

74

keypoint

APRIL 16, 2024

The prize has been awarded annually since 2017, as a collaboration between the Michelson Medical Research Foundation and the Human Immunome Project.

Vaccine 80

Vaccine International Research 80

Broad Institute

OCTOBER 11, 2023

The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017. Together, Haining, Manguso , and Yates went on to found the Tumor Immunotherapy Discovery Engine ( TIDE ) at the Broad Institute of MIT and Harvard in 2017 with support from Calico as a collaborating partner.

Research 137

Research Immune Response Clinical Trials Therapies 137

Broad Institute

OCTOBER 4, 2023

AbbVie and Calico discovered the molecule, called ABBV-CLS-484 , after TIDE researchers at Broad identified the PTPN2 gene as a promising cancer immunotherapy target in 2017. It still sort of stuns me that we went from discovering a target in 2017 to testing drugs in patients starting in 2020,” Yates said.

Small Molecule 128

Small Molecule Clinical Trials Engineering Trials 128

SCIENMAG: Medicine & Health

JULY 20, 2023

Peanut introduction is not well known among those with less access to health-care information Having a pediatrician recommend early peanut introduction was best way for parents/caregivers to be informed Fear of an allergic reaction is the main reason parents decline, but only 1% infants had a reaction, which was mild CHICAGO — In 2017, the National (..)

70

70

SCIENMAG: Medicine & Health

JULY 17, 2023

E-cigarette use more than doubled from 2017 to 2019 among middle and high school students. Statement Highlights: The number of people who use electronic nicotine delivery systems, typically referred to as e-cigarettes, has grown exponentially, especially among youth and young adults.

Research 67

Research 67

Drugs.com

MAY 13, 2024

MONDAY, May 13, 2024 -- Police seizures of illicit fentanyl pills have soared in recent years, a new study has found.The number of pills containing fentanyl seized by law enforcement was 2,300 times greater in 2023 than in 2017 – more than 115.

59

59

Eye on FDA

AUGUST 10, 2023

The number of press releases issued by FDA during the first six months of the year declined to 101 from the 125 issued by June 30 of last year, the lowest number at mid-year since 2017. In 2018, FDA issued a much larger number of releases – trend that continued through 2022, all years with much larger numbers than were seen in 2017.

FDA 80

FDA 80

NIOSH Science Blog: Drugs

AUGUST 2, 2023

Based on data from the OHBWC claims database, the researchers analyzed a comprehensive set of injury claims filed by firefighters from 2001-2017. The objective was to characterize the demographics of firefighter claimants, most frequent injury events, common diagnoses, and

Research 68

Research 68

SCIENMAG: Medicine & Health

AUGUST 11, 2023

About The Study: This survey study of 5,035 adults found that adults increasingly perceived daily smoking and secondhand exposure to cannabis smoke as safer than tobacco smoke from 2017 to 2021.

Science 63

Science 63

Agency IQ

MARCH 25, 2024

Europe enacted the medical device (MDR) and IVD regulations (IVDR) in May 2017 but gave manufacturers and other stakeholders, including the regulators themselves, time for implementation. Our new resource aims to help make this a little bit easier. Fill out the form to read the full article.

Regulations 59

Regulations 59

Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

Drugs 72

Drugs Research 72

Drug Patent Watch

DECEMBER 12, 2024

Generics 2030: Three strategies to curb the downward spiral. Retrieved from [link] The Commonwealth Fund. Strategies That Delay Market Entry of Generic Drugs. Retrieved from [link] Bollyky, T. J., & Kesselheim, A. Ten challenges in the prescription drug marketand ten solutions. Retrieved from [link] Gottlieb, S.

Marketing 94

Marketing Drugs FDA FDA Approval 94

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations. Fill out the form to read the full article.

FDA 59

FDA Production Drugs 59

New Drug Approvals

NOVEMBER 13, 2023

WO 2017/208267A1, WO 2020/250133 Al and WO 2022/024072A1, which are hereby incorporated by reference, disclose methods of use of the compound of Formula I for the treatment of Parkinson’s disease, synucleinopathies and Alzheimer’s disease (AD) respectively. amcrasto@amcrasto /////////// Ref [1]. amcrasto@amcrasto /////////// Ref [1].

Treatment 62

Treatment Disease Therapies Production 62

Drug Target Review

OCTOBER 26, 2023

Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food and Drug Administration (FDA) to treat inherited retinal dystrophy in 2017, respectively. Wang D, Tai PW, Gao G.

Engineering 105

Engineering Virus Therapies Immune Response 105

Common Sense for Drug Policy Blog

MARCH 4, 2024

Deaths from Excessive Alcohol Use in the US, 2016-2021 "From 2016–2017 to 2020–2021, the average annual number of U.S. deaths from excessive alcohol use increased by more than 40,000 (29%), from approximately 138,000 per year (2016–2017) to 178,000 per year (2020–2021).

52

52

SCIENMAG: Medicine & Health

JULY 5, 2023

In 2017, the Nobel Prize in Medicine was bestowed upon researchers who made significant breakthroughs in […] Living organisms possess an internal biological cycle known as the circadian clock, enabling them to adapt to environmental changes arising from the Earth’s rotation.

International 59

International Regulations Research 59

Broad Institute

MARCH 8, 2024

Any questions about the Next Generation Awards program can be directed to Jacob Herman at jherman@broadinstitute.org.

Research 52

Research 52

SCIENMAG: Medicine & Health

AUGUST 9, 2023

T1DC was established in 2017 […] TUCSON, Ariz., August 9, 2023 — Critical Path Institute (C-Path) announced today that Sanofi, a global leader in immunology and diabetes care, has joined its Type 1 Diabetes Consortium (T1DC).

Drug Development 57

Drug Development Drugs 57

Drug Target Review

JANUARY 25, 2024

2017 March 21 [2024 January 18]; Available from: [link] 2 Carey LA, Irvin WJ. This study was published in Molecular Cancer Therapeutics. References 1 Marqus S, Pirogova E, Piva TJ. Evaluation of the use of therapeutic peptides for cancer treatment. Journal of Biomedical Science. What is triple-negative breast cancer?

Treatment 105

Treatment Clinical Trials Science Research 105

Eye on FDA

AUGUST 17, 2022

You can see early in the chart, FDA maintained a very low volume of communications, and at mid-year in 2017 had issued only 52 releases, rising to 166 for the year. This year at 128 mid-year, the agency is at the lowest level since then.

FDA 75

FDA Production 75

Drug Hunter

JUNE 5, 2023

Glecaprevir, or ABT-493, was approved in combination with pibrentasvir (Mavyret) for the treatment of Hepatitis C (HCV) in 2017. The Enabling Route to ABT-493/Glecaprevir A good example of the details that can be involved in RCM optimization comes from AbbVie and Enanta’s glecaprevir.

Process Chemistry 206

Process Chemistry Drugs Production Clinical Development 206

New Drug Approvals

OCTOBER 12, 2024

ALZ-801 is converted to homotaurine in vivo, but is more easily absorbed and lasts longer in the blood than tramiprosate. Tramiprosate was reported to inhibit Aβ42 aggregation into toxic oligomers ( Gervais et al., 2007 ; Kocis et al., 2016 ; Abushakra et al., Alzheon licensed ALZ-801 from NeuroChem and is developing it for Alzheimer’s disease.

Pharmacokinetics 62

Pharmacokinetics Small Molecule Disease Licensing 62

Drug Patent Watch

NOVEMBER 9, 2022

This chart shows the generic pharmaceutical companies that had the most successful drug patent challenges from 2017 to 2022. Companies that successfully challenge patents on branded drugs are granted six…. The post Most prolific drug patent challengers appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies 52

Pharmaceutical Companies Drugs Pharmaceuticals 52