Drug Target Review
NOVEMBER 1, 2023
He formerly worked at EMBL as a postdoctoral fellow from 2017 to 2020 where he discovered the inhibition of ATX with THC. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. 2017 Mar 9;60(5):2006–17. 2018 Jun 13;5.
The Pharma Data
MARCH 16, 2022
The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.
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Drug Target Review
OCTOBER 2, 2024
Continued growth in the field relies on multidisciplinary efforts combining biology, engineering, and clinical medicine. Ongoing innovation in stem cell biology, gene editing, delivery technologies, and advanced biomaterials is likely to address many of the current obstacles. 2017 May 31;58(3):435-440. Epub 2017 May 23.
Drug Target Review
AUGUST 24, 2023
in North America) in late 2017. Coordinated integrin activation by actin-dependent force during T-cell migration. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. References Nordenfelt P, Elliott HL, Springer TA.
Broad Institute
OCTOBER 11, 2023
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.
NIH Director's Blog: Drug Discovery
APRIL 11, 2017
2017 Apr 3;8:14932. PLoS Negl Trop Dis. 2014 Jan 9;8(1):e2628. [2] 2] Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases. Yu H, Dranchak P, Li Z, MacArthur R, Munson MS, Mehzabeen N, Baird NJ, Battalie KP, Ross D, Lovell S, Carlow CK, Suga H, Inglese J. Nat Commun.
Drug Target Review
NOVEMBER 17, 2023
By themselves, the NK cells showed limited efficacy, but anti-tumour efficacy was observed with co-treatment regimens (eg, monoclonal antibodies, haematopoietic stem cell transplants, whole body irradiation) and multiple dosing (tolerated well by patients).
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