Drug Target Review

OCTOBER 2, 2024

For example, integrating gene therapies that alter the DNA of cardiac cells pose risks of unintended genetic modifications, which could lead to tumorigenesis. Continued growth in the field relies on multidisciplinary efforts combining biology, engineering, and clinical medicine. 2017 May 31;58(3):435-440. Int Heart J.

Therapies 52

Therapies Disease Engineering RNA 52

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.

Research 137

Research Immune Response Clinical Trials Therapies 137

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., 50 , 1700391 (2017). Genetics 205 , 1003–1035 (2017). 16 , 70–70 (2017). 44 , 195–211 (2017). by altering its accessibility to transcriptional machinery).

Disease 87

Disease Treatment Drugs Clinical Trials 87

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). PLoS Biology (2017).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). PLoS Biology (2017).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52