2017 Cell Biology Drug Development 
NIH Director's Blog: Drug Discovery
APRIL 11, 2017
Before testing their peptides in animal models, they’ll continue to tinker with them in search of a version effective in disabling iPGM that might also make its way into cells more easily. Drug development is a notoriously long and arduous process, which too often ends in disappointment. 2017 Apr 3;8:14932. Nat Commun.
Broad Institute
OCTOBER 11, 2023
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.
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Drug Target Review
SEPTEMBER 19, 2023
In addition, these models at the current state are better for short term tests, over a week or two and cannot be used for acquiring data from long term drug exposures. Miniature organs as test beds for new drugs Organoids are miniature human organs with clusters of cells derived from stem cells and mimic specific tissues.
DrugBank
JUNE 27, 2023
The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care. Drug Discov.
Codon
APRIL 9, 2024
Department of Defense administered mefloquine, the synthetic drug developed at Walter Reed in the U.S., only issued “the strongest ‘black box’ warning” against the drug in 2013. have been poured into replicating work already done” by Chinese scientists decades ago. Nobody had an answer.
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