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To curb glucuronidation at that position a gem-dimethyl group was incorporated which not only boosted metabolicstability, but also resulted in increased potency of the final lead compound. 8(2):3640-3648; [link] [11] Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality. Oncotarget.
2017, 30, 1, 13–37 [link] 2a Drug Metab. 2010, 75, 9, 3141–3143 [link] 22 Clin Pharmacokinet. 44, 797–814 [link] Take a look at our other blogs The post Metabolism of five membered nitrogen containing heterocycles appeared first on Hypha Discovery. Instead, be on the lookout for N -glucuronides. References 1 Chem.
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