Drug Target Review

MARCH 15, 2024

As discussed above, recent advances in gene editing tools and transposon-based vectors have facilitated targeted and consistent cell line engineering for the development of protein expressing CHO cell lines. 2017 Nov;33(6):1468-1475. Epub 2017 Sep 7. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014.

Engineering 105

Engineering Molecular Biology Protein Expression Medical Schools 105

PPD

OCTOBER 12, 2023

These treatments use a vector to introduce the desired nucleic acid code to replace or modify protein expression or use cells to alter/restore a specific cell type. Cell and gene therapies (CGTs) are one of the fastest growing areas in human therapeutics.

Laboratories 52

Laboratories Protein Expression Clinical Trials Pharmacokinetics 52

PerkinElmer

AUGUST 25, 2019

The Results, Please Dr. Hinterneder’s research confirms that PD-L1 protein expression levels in human cells can be quickly and accurately assessed with the AlphaLISA human PD-L1 assay. This light emission can be detected on an Alpha-enabled reader such as the PerkinElmer EnVision ® multimode plate reader.

Protein Expression 52

Protein Expression Immune Response Treatment Research 52

Broad Institute

OCTOBER 4, 2023

As reported last year in ACS Chemical Biology , Wang’s lab developed a way to construct messenger-oligonucleotide conjugated RNAs with chemically modified tails, a strategy that reduced RNA degradation while increasing therapeutic protein expression in cells. Wang concluded her presentation by expressing gratitude to Merkin.

DNA 52

DNA RNA Science Protein Expression 52

Drug Target Review

SEPTEMBER 4, 2023

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. doi.org/10.5772/intechopen.770301 770301 Mark, C. Michael, A. and Ian, H. doi:10.1038/nrmicro.2016.193.

Drugs 111

Drugs RNA DNA Disease 111

The Pharma Data

MARCH 8, 2021

OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick. Food and Drug Administration (FDA) in July 2017 3. VLA15 has demonstrated strong immunogenicity and safety data in pre-clinical and clinical studies so far. The program was granted Fast Track designation by the U.S.

Vaccine 52

Vaccine Disease Protein Expression Trials 52

The Pharma Data

SEPTEMBER 28, 2021

In addition, results from Part 1 of Study SRP-9001-102, an ongoing, randomised, double-blind, placebo-controlled clinical test evaluating the security , efficacy, and tolerability of one dose of SRP-9001 in 41 boys with DMD, showed that the study met its primary biological endpoint of change in micro-dystrophin protein expression from baseline.

Clinical Trials 52

Clinical Trials Protein Expression Therapies FDA 52