The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. CEPI is an innovative partnership between public, private, philanthropic, and civil organisations, launched at Davos in 2017, to develop vaccines to stop future epidemics.

Clinical Trials 52

Clinical Trials Vaccine Trials Virus 52

Drug Target Review

AUGUST 24, 2023

Her discoveries on the first-in-class RNA-based innate immune receptor agonist RGT100, built the foundation for the initiation of a Phase I clinical trial as well as the successful acquisition of Rigontec by MSD (known as Merck & Co. in North America) in late 2017.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

BMG Labtech

OCTOBER 4, 2023

In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments. DNA extraction and quality control Before sequencing can start, nucleic acid samples (DNA or RNA) must be prepared for analysis which involves their extraction from a biological sample.

DNA 52

DNA RNA Bioinformatics Research 52

New Drug Approvals

JANUARY 31, 2024

2-NTP , an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and transcription of viral RNA. 2017, 60, 1648-1661) in tetrahydrofuran (THF) was added N,N-dimethylaminopyridine (DMAP) (0.03 Strong clinical results for 1 have prompted interest in oral approaches to generate 2-NTP. Woolner, E.;

RNA 52

RNA Science Treatment Pharmacokinetics 52

The Pharma Data

DECEMBER 3, 2020

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. CEPI is an innovative partnership between public, private, philanthropic, and civil organizations, launched at Davos in 2017, to develop vaccines to stop future epidemics.

Vaccine 52

Vaccine Immune Response Virus RNA 52

Drug Target Review

APRIL 3, 2024

Her discoveries on the first-in-class RNA-based innate immune receptor agonist RGT100, built the foundation for the initiation of a Phase I clinical trial as well as the successful acquisition of Rigontec by MSD (known as Merck & Co. in North America) in late 2017.

Science 106

Science Clinical Development Treatment DNA 106

The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. CEPI is an innovative partnership between public, private, philanthropic, and civil organisations, launched at Davos in 2017, to develop vaccines to stop future epidemics.

Vaccine 52

Vaccine Trials Virus RNA 52

Alta Sciences

APRIL 17, 2024

The FDA approved the first gene therapy in 2017 for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia (ALL), and as of December 2023, there are over 30 approved cell and gene therapies on the market in the U.S.A. Read The Altascientist , “Nonclinical Studies in Cell and Gene Therapy”. 3.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

Drug Target Review

OCTOBER 2, 2024

RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. 2017 May 31;58(3):435-440. Epub 2017 May 23. By correcting these mutations, gene-modifying and editing therapies hold the promise of long-term, potentially curative treatments. Int Heart J.

Therapies 98

Therapies Disease Engineering RNA 98

Broad Institute

OCTOBER 11, 2023

The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017. Together, Haining, Manguso , and Yates went on to found the Tumor Immunotherapy Discovery Engine ( TIDE ) at the Broad Institute of MIT and Harvard in 2017 with support from Calico as a collaborating partner.

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 2017): Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need, Nature Review Microbiology, 15(4): 217–231. We discovered it is highly effective and environmentally friendly. Michael, A.

Drugs 111

Drugs RNA DNA Disease 111

Drug Target Review

AUGUST 9, 2023

14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts. Many potential toxic effects have been suggested, including the mis-splicing of the Stathmin-2 RNA transcript. 2017, [link] Huber, N., Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.”

RNA 98

RNA Regulations Disease DNA 98

Drug Target Review

MARCH 21, 2024

Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow. AAV-based therapies often can’t be dosed more than once due to concerns about an immune response. mdx mutant mice treated with mRNA-DMD?

Therapies 65

Therapies RNA Immune Response Treatment 65

Broad Institute

OCTOBER 4, 2023

Today, scientists use such reactions to produce the customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and more. It is because we had the Fellowship that we could buy our very first DNA and RNA synthesizer in the lab.”

DNA 52

DNA RNA Science Protein Expression 52

Codon

APRIL 19, 2023

A group of Australians were the first to make that happen; in 2017, they took a single gene from a nematode, pasted it into the genome of a Cavendish tree, and showed that the gene-edited plants were completely resistant to the fungi. in Nature Communications (2017). Banana trees infected with Fusarium wilt are frail and brown.

DNA 52

DNA RNA Engineering Regulations 52

Codon

APRIL 19, 2023

A group of Australians were the first to make that happen; in 2017, they took a single gene from a nematode, pasted it into the genome of a Cavendish tree, and showed that the gene-edited plants were completely resistant to the fungi. in Nature Communications (2017). Banana trees infected with Fusarium wilt are frail and brown.

DNA 52

DNA RNA Engineering Regulations 52

The Pharma Data

MARCH 4, 2021

Under the 2017 collaboration agreement, Takeda received equity in Ovid and was eligible to receive up to $85 million in payments for regulatory milestones, including the initiation of Phase 3 clinical trials. For more information on Ovid, please visit www.ovidrx.com. .

Treatment 52

Treatment Clinical Trials Pharmaceutical Companies Trials 52

The Pharma Data

NOVEMBER 1, 2021

The project, detailed in an open-access paper in Computers in Biology and Medicine, incorporates models of three drug targets – main protease (Mpro), RNA-dependent RNA polymerase (RdRp) and Papain-like protease (PLpro) – for ensemble docking through DINC-COVID.

Virus 52

Virus RNA Drugs Engineering 52

New Drug Approvals

SEPTEMBER 29, 2024

2017 ; Ilievski et al., In addition, older dogs had bacterial antigens and ribosomal RNA in their brains, consistent with systemic infection seen in humans. Epub 2017 Nov 6 PubMed. In preclinical work from other labs, infection with P. 2018 ; Ding et al., For a review of the preclinical literature, see Costa et al.,

Small Molecule 62

Small Molecule DNA Disease Trials 62

The Open Targets Blog

APRIL 5, 2023

We then designed our own CRISPR guide RNA library against the druggable genome and transduced the corresponding lentiviruses into millions of our iNeurons. After treating the cells with tunicamycin to induce ER stress, we looked for guide RNAs that were enriched in the cells that survived treatment compared to untreated cells.

Small Molecule 52

Small Molecule Disease RNA Treatment 52

Codon

MARCH 12, 2023

The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Eterna is an online game (there’s also an app) where anyone on the internet can solve puzzles by manipulating RNA sequences and simulating the results. Biology is a Burrito.

DNA 52

DNA Engineering Therapies RNA 52

Broad Institute

JANUARY 27, 2025

Generating data with the method is more than 10 times less expensive than comparable high-dimensional approaches such as high-throughput single-cell RNA sequencing and can be adapted to study a wide variety of cell types.

DNA 131

DNA RNA Science Research 131

Broad Institute

OCTOBER 27, 2024

Our proposed method will be evaluated on synthetic zero-inflated count datasets, simulated single-cell RNA sequencing (scRNA-seq) data, and real-world multi-sample multi-condition scRNA-seq datasets.

RNA 40

RNA Research 40

Drug Target Review

DECEMBER 16, 2024

Since their first approvals in 2017, autologous CAR T-cell therapies have revolutionised the treatment of blood cancers, offering hope where previous options had failed. With the first approvals of CD19 CAR T-cells in 2017, treatment outcomes for patients improved dramatically.

Therapies 52

Therapies Clinical Trials Treatment Trials 52

Broad Institute

NOVEMBER 6, 2024

Launched in 2017, this is a first-of-its-kind program in North America focused on improving the diagnosis, treatment, and understanding of serious immunotherapy complications, which can affect nearly every organ system. Tags: Cancer RNA sequencing Paper Cited Blum S, Zlotoff D, et al. Online November 6, 2024.

Immune Response 125

Immune Response Medical Schools Clinical Trials Treatment 125

Codon

AUGUST 10, 2023

PLoS Biology (2017). Nature (2017). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2017). Current Genetics (2017). Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. & Xie X.S. PNAS (2004).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

PLOS: DNA Science

DECEMBER 21, 2023

It’s a history of gene therapy told through the voices of the patients, families, researchers, and clinicians behind the first FDA approvals, which didn’t come until 2017. I am grateful to PLoS for giving me this voice for more than a decade, and free reign to cover anything that even remotely involves DNA or RNA.

DNA 105

DNA Vaccine Science Therapies 105

Codon

AUGUST 10, 2023

PLoS Biology (2017). Nature (2017). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Science (2017). Molecular Cell (2017). Link In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation , by Jewett M.C. & Xie X.S.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

PLOS: DNA Science

FEBRUARY 29, 2024

In 2017, I reposted the essay in response to a document from the Department of Health and Human Services citing its role of “serving and protecting Americans at every stage of life, beginning at conception.” But maternal genetic information, in the form of messenger RNA “transcripts,” still guides development.

DNA 97

DNA Science Medical Schools RNA 97