2018 and Biochemical Assays - Drug Discovery Digest

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2018

Biochemical Assays

Unique self-activating proteins for drug discovery

Drug Target Review

JANUARY 5, 2024

Å resolution) 6 is now being targeted for small molecule inhibitor discovery and development, by exploiting emergent computational tools to identify potential candidate compounds in silico and then test these predicted inhibitors in in vitro biochemical assays. Cancer Treat Rev. 1990;17(2-3):233-42. doi: 10.1016/0305-7372(90)90053-i.

Small Molecule

Small Molecule Drugs Biochemical Assays Regulations

We Need Better Benchmarks for Machine Learning in Drug Discovery

Practical Cheminformatics

AUGUST 3, 2023

Of the 404 molecules labeled as CA, 68 are azo dyes widely known to be cytotoxic and generate assay interference. I wrote more about the problems with this dataset in a Practical Cheminformatics post in 2018. Initially, I would recommend aqueous solubility, membrane permeability, in vitro metabolic stability, and biochemical assays.

Drugs

Drugs Biochemical Assays Metabolic Stability Screening Hits

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Unique self-activating proteins for drug discovery

We Need Better Benchmarks for Machine Learning in Drug Discovery

Webinars

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