article thumbnail

Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field.

Disease 98
article thumbnail

New molecular insights on medical cannabis

Drug Target Review

2018 Jun 13;5. Role of autotaxin in cancer stem cells. 2018 Sep;37(2–3):509–18. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. References: Ninou I, Magkrioti C, Aidinis V. Frontiers in Medicine.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Building better brain models for Parkinson’s disease and beyond

Drug Target Review

Turning this tide, Professor Jens Christian Schwamborn, a cell biology expert at the University of Luxembourg and co-founder of OrganoTherapeutics , is leading a groundbreaking effort to transform our understanding and treatment of these debilitating diseases.

Disease 52
article thumbnail

Women in Stem with Ashley Hall

Drug Target Review

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

article thumbnail

Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology.

article thumbnail

Innate Pharma 2021 Financial Calendar

The Pharma Data

Innate Pharma’s commercial-stage product, Lumoxiti, in-licensed from AstraZeneca in the US, EU and Switzerland, was approved by the FDA in September 2018. Lumoxiti is a first-in class specialty oncology product for hairy cell leukemia.

article thumbnail

A Ray of Molecular Beauty from Cryo-EM

NIH Director's Blog: Drug Development

2018 Jun;558(7711):553-558. [2] 2018 Apr;93(4):251-258. [3] Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE. Many Targe Sriram K, Insel PA. Mol Pharmacol.