2018 Cell Biology Disease 
Drug Target Review
MARCH 3, 2025
The search for effective treatments for neurodegenerative diseases like Parkinson’s disease has long been hindered by the brain’s complexity and the absence of adequate models for drug discovery. From stem cell to organoid The process of developing a usable organoid from stem cells takes time.
Drug Target Review
JULY 13, 2023
Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field. Dewpoint’s breakthrough was the realisation that certain condensates are associated with human diseases. The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0”
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Drug Target Review
NOVEMBER 1, 2023
2 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 1-5 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 2018 Jun 13;5. Role of autotaxin in cancer stem cells.
Drug Target Review
OCTOBER 31, 2023
When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.
DrugBank
JUNE 27, 2023
Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. 9 Polygenic diseases are much more common, and thousands of genetic variants with very small effects could impact their phenotype.
Drug Target Review
AUGUST 24, 2023
These findings were mirrored in the clinical results from an analysis of two metastatic melanoma patient cohorts who received anti-PD-1 treatment: patients with responses and disease control had significantly lower GDF-15 serum levels (measured before treatment start), while none of the patients with elevated GDF-15 levels showed a lasting response.
NIH Director's Blog: Drug Development
SEPTEMBER 20, 2018
2018 Jun;558(7711):553-558. [2] 2018 Apr;93(4):251-258. [3] Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE. Many Targe Sriram K, Insel PA. Mol Pharmacol.
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