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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

In recent years, a novel approach known as condensate biology has emerged, revolutionising the way researchers think about drug discovery and development. Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field.

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Women in Stem with Ashley Hall

Drug Target Review

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

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Who are the AACR Scientific Achievement Award winners?

Drug Discovery World

Kathryn E Wellen, PhD – Outstanding Achievement in Basic Cancer Research Wellen is an investigator at the Penn Epigenetics Institute and Vice Chair and Professor in the Department of Cancer Biology in the Perelman School of Medicine at the University of Pennsylvania. Mak’s award lecture will be held on Sunday April 16 at 12pm ET.

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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology.

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A Ray of Molecular Beauty from Cryo-EM

NIH Director's Blog: Drug Development

That includes those involved in regulating our appetites and our moods, via a class of G proteins known as inhibitory G proteins (G i ). 2018 Jun;558(7711):553-558. [2] 2018 Apr;93(4):251-258. [3] They share a common architecture and bind a relatively limited number of intracellular signaling proteins called G proteins.

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Precision Medicine in the Genomic Era

DrugBank

14 As an unbiased method for genetic variant detection, GWAS holds the promise of identifying new genes and gene regulation mechanisms underlying a variety of conditions, including complex diseases. Public Health 39 , 153–168 (2018). 33 , 11–12 (2018).  Obama White House Archive.  Jaccard, E.,

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The Codon Guide to Synthetic Biology

Codon

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Artificial Life (2018).

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