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Building better brain models for Parkinson’s disease and beyond

Drug Target Review

Turning this tide, Professor Jens Christian Schwamborn, a cell biology expert at the University of Luxembourg and co-founder of OrganoTherapeutics , is leading a groundbreaking effort to transform our understanding and treatment of these debilitating diseases.

Disease 52
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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. Current Opinion in Cell Biology. Biophysical Journal.

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Women in Stem with Ashley Hall

Drug Target Review

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

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Precision Medicine in the Genomic Era

DrugBank

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. Public Health 39 , 153–168 (2018). 33 , 11–12 (2018). Network expansion of genetic associations defines a pleiotropy map of human cell biology.  Obama White House Archive.

Disease 98
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First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

INTERLINK-1 represents first Phase 3 study examining IO approach in R/M SCCHN patients who have been treatedwith a platinum-based therapy and PD-(L)1 inhibitor. Overall, the combination therapy data to date supports the expedited development of monalizumab and cetuximab in this indication. MARSEILLE, France, Oct.

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Making Eggs Without Ovaries

Codon

Activated follicles will mature into antral follicles, consisting of a fully grown oocyte surrounded by several layers of different types of ovarian somatic cells. In 2018, Saitou’s team reported the first method to coax human PGC-like cells into the oogonia stage.

DNA 112
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The Codon Guide to Synthetic Biology

Codon

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Artificial Life (2018).

DNA 98