Drug Target Review

MAY 31, 2024

I currently lead a talented team of multi-disciplinary scientists who are dedicated to discovering a treatment for Parkinson’s Disease, a debilitating condition with significant unmet medical need. About the author Dr H Rachel Lagiakos Senior Principal Scientist, Therapeutics Group at Schrodinger Dr Lagiakos joined the company in 2018.

Organic Chemistry 45

Organic Chemistry Computational Chemistry Small Molecule Disease 45

Drug Discovery World

SEPTEMBER 5, 2022

These non-coding contributors can also lower protein expression levels, and are generally missed,” says Dr Olga Troyanskaya, Professor at Princeton University, who specialises in developing machine learning models to interpret disease complexity. “In Algorithms essentially learn the regulatory code to make predictions.

Drug Development 130

Drug Development Drugs Protein Expression Therapies 130

Drug Target Review

SEPTEMBER 20, 2023

“AI will not replace drug discovery scientists, but drug discovery scientists who use AI will replace those who don’t” – comment during EFMC meeting 2018 Progressing a drug molecule from concept to commercialisation typically takes 10-15 years and has high associated costs of up to $2 billion per launched drug, if all failures are factored in.

Drugs 105

Drugs Metabolic Stability Computational Chemistry Pharmaceuticals 105

LifeSciVC

APRIL 27, 2023

The premise at the time was that putting computational chemistry in the primary position for new molecule ideation would upend the drug discovery paradigm. set up a “virtual project team,” leverage Schrödinger scientists to lead computational chemistry, and do all the wet work at CROs. It did just that.

Small Molecule 52

Small Molecule Computational Chemistry Engineering Clinical Development 52