Drug Discovery World

JANUARY 3, 2023

Matthew Clark , CEO of X-Chem, looks at what the future could hold for DNA-encoded library (DEL) technology. In the 13 years since it was first described, DNA-encoded library (DEL) technology has become a firmly established approach to small molecule hit generation in drug discovery. This makes a TPD-DEL workflow quite efficient.

DNA 130

DNA Targeted Protein Degradation Small Molecule Pharma Companies 130

Drug Discovery World

MAY 30, 2023

These targeted cytokines are selectively removed with the intention of neutralising the cancer’s ability to block a patient’s natural immune defence mechanisms, which are significantly compromised in late-stage, metastatic disease. This potentially re-energises the immune system to fight cancers.”

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Research Targeted Protein Degradation Drugs RNA 130

Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. This targeted delivery allows enhanced therapeutic efficacy while reducing the harmful side effects commonly associated with traditional chemotherapy.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 125