The Pharma Data

NOVEMBER 17, 2020

The study demonstrated favorable proof-of-concept for LYT-100’s tolerability and pharmacokinetic (PK) profile, which will also enable twice-a-day (BID) dosing of LYT-100 in future studies. IPF, unclassifiable interstitial lung diseases (uILDs), Long COVID respiratory complications and related sequelae) and lymphedema.

Pharmacokinetics 52

Pharmacokinetics Treatment Production Small Molecule 52

New Drug Approvals

SEPTEMBER 13, 2024

2] As of July 2022, it is in phase 3 clinical trials for major depressive disorder. [2] hours following a single dose of 10 mg, which supported the 4 mg to 25 mg dosages that aticaprant is being explored at in clinical trials. [13] 14] Pharmacokinetics The oral bioavailability of aticaprant is 25%. [1] nM vs. 24.0 nM vs. 24.0

Treatment 62

Treatment Pharmacokinetics Clinical Trials Pharmaceuticals 62

Drug Discovery World

AUGUST 10, 2022

And now, with more than 600 CAR T trials recruiting or ongoing, these cells represent a majority of the cellular immunotherapies in development today. Measuring the pharmacokinetics of CAR T cells. The donor cells could potentially attack healthy tissues, thereby inducing graft-vs-host disease. 2018) 4;8:163.

Therapies 246

Therapies Virus Treatment Engineering 246

The Pharma Data

AUGUST 22, 2021

The trial accrued 25 cases of symptomatic COVID-19 at the primary analysis.There were no cases of severe COVID-19 or COVID-19-related deaths in those treated with AZD7442. The trial included 5,197 participants in a 2:1 randomisation AZD7442 to placebo. The trial was conducted in 87 sites in the US, UK, Spain, France and Belgium.

Trials 52

Trials Virus Vaccine Pharmacokinetics 52

The Pharma Data

DECEMBER 21, 2020

UBX1325 is developed from BM-962, a Bcl-xL inhibiting compound licensed to UNITY by Ascentage Pharma for the treatment of age-related diseases. UNITY is a biotechnology company developing therapeutics to extend healthspan by slowing, halting or reversing diseases of aging. SUZHOU, China and ROCKVILLE, Md. , Ascentage Pharma (6855.HK)

Clinical Development 40

Clinical Development Disease Treatment Licensing 40

The Pharma Data

APRIL 8, 2021

OCREVUS data show its consistent benefit on slowing disease progression in relapsing multiple sclerosis (RMS) and primary progressive MS (PPMS). Data for ENSPRYNG in neuromyelitis optica spectrum disorder (NMOSD) reinforce safety and efficacy, including in patients with concomitant autoimmune diseases (CAIDs). Following U.S.

Clinical Trials 52

Clinical Trials Trials Disease Nurses 52

Drug Discovery World

FEBRUARY 15, 2023

Cancer is a complex heterogenous multistep disease characterised by uncontrolled cell proliferation combined with a dysregulated immune response. The number of new cases recorded between 2016 and 2018 was 375,400, with 167,142 deaths caused by cancer between 2017 and 2019.

Research 130

Research Therapies Immune Response Clinical Trials 130

The Pharma Data

FEBRUARY 8, 2021

Patients in the trial received either a combination of ERLEADA ® and ZYTIGA ® plus prednisone (combination arm) or placebo and ZYTIGA ® plus prednisone (control arm). [i] Food and Drug Administration (FDA) approval for nmCRPC on February 14, 2018 and was approved for mCSPC on September 17, 2019. FDA on February 8, 2018. [vi]

Pharmaceutical Companies 52

Pharmaceutical Companies Treatment Clinical Trials Trials 52

Agency IQ

FEBRUARY 23, 2024

Obesity itself contributes to multiple long-term consequences , including high blood pressure and high cholesterol, which in turn increase the risk of heart disease. That passage is referred to as pharmacokinetics (PK) and incorporates four important phases – absorption, distribution, metabolism, and excretion (ADME).

Drugs 40

Drugs Clinical Trials Pharmacokinetics Drug Development 40

The Pharma Data

FEBRUARY 25, 2021

FIREFISH Part 1 data show treatment with Evrysdi at 12 months helped 90% of these infants survive without permanent ventilation and 33% sit without support, a key motor milestone not normally seen in the natural course of the disease. Enrollment for Part 2 was completed in November 2018. mg/kg for Part 2. About Evrysdi (risdiplam).

Pharmacokinetics 52

Pharmacokinetics FDA Approval Treatment Disease 52

The Pharma Data

MARCH 20, 2023

Professor of Paediatric Neuromuscular Diseases at the MDUK Oxford Neuromuscular Centre. This trial included people with Type 2 and 3 SMA, including patients with advanced disease. Adverse events (AEs) and serious adverse events (SAEs) were reflective of the underlying disease. Food and Drug Administration in 2017.

Pharmacokinetics 40

Pharmacokinetics Treatment Clinical Trials Trials 40

The Pharma Data

OCTOBER 6, 2021

.” In August, 2021, AstraZeneca declared high- position results from the PROVENTpre-exposure prophylaxis trial which showed AZD7442 reduced the imminence of developing discriminating COVID-19 by 77 (95 confidence interval (CI) 46, 90), compared to placebo. The trial accrued 25 cases of discriminating COVID-19 at the primary analysis.

Pharmacokinetics 52

Pharmacokinetics Government Trials Vaccine 52

The Pharma Data

MARCH 30, 2021

Evrysdi has proven efficacy in adults, children and babies two months and older, as shown in two pivotal clinical trials. More than 3,000 patients now treated with Evrysdi in clinical trial, compassionate use and real-world settings. SMA is a leading genetic cause of death in infants and 5q SMA is the most common form of the disease.

Treatment 52

Treatment Clinical Trials Pharmacokinetics Trials 52

The Pharma Data

MARCH 16, 2021

SUNFISH Part 2 study population includes broad range of ages and disease severities, representing a real-world spectrum of people living with Type 2 or 3 SMA. More than 2,500 patients now treated with Evrysdi in clinical trial, compassionate use and real-world settings. Enrollment for Part 2 was completed in November 2018.

Pharmacokinetics 52

Pharmacokinetics Treatment Clinical Trials Disease 52

The Pharma Data

SEPTEMBER 27, 2020

These results build on the efficacy and safety demonstrated by Evrysdi in pivotal trials, and we look forward to continued assessments of both survival and motor function during long-term follow up for this first-of-its-kind treatment.”. Enrolment for Part 2 was completed in November 2018. months and the oldest was 45.1 months of age.

Pharmacokinetics 52

Pharmacokinetics FDA Approval Treatment Clinical Trials 52