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Gene editing extends lifespan in mouse model of prion disease

Broad Institute

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration. We should be able to do something with this.

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Epigenetic editing: the next generation of genetic medicine

Drug Target Review

The reasons for this are multifaceted, including concerns over the safety of directly altering DNA sequences and subsequent regulatory restrictions that have arisen as a result. The epigenome (meaning ‘above the genome’) is a system of reversible marks regulating how the DNA is read, translated and used. What is epigenetic editing?

DNA 105
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Not all neoantigens are created equal

Drug Target Review

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

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Key considerations before commencing cell line development

Drug Target Review

After binding, the transposase enzyme will excise the flanked section of DNA (termed the transposon) and insert it into sites in the genome at specific target sequences. A potential future for host cell lines There have been many recent advances in cell line engineering technologies and our understanding of CHO cells. Biotechnol.

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Farma: Speculative Gastronomy

Codon

Genetic engineering in the medicine cabinet is one thing; allowing it at the dinner table is another. The chefs at Farma know that by embracing food technologies such as recombinant DNA, precision fermentation, and cell culture, food can become more nutritious and better for the planet. In 2018, for example, the U.S.

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The Long Road to End Tuberculosis

Codon

Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis. Testing the engineered cells against four common drugs, I found that the M. In 2018, GlaxoSmithKline (GSK) piloted a new vaccine that may outmatch the BCG vaccine in treating pulmonary TB in adults.

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Mechanisms underlying pioneer TF-mediated gene repression

Drug Target Review

Pioneer TFs can recognise their target DNA sequences in compacted heterochromatin and can trigger remodelling of the adjoining chromatin landscape to provide accessibility to nonpioneer TFs. 2018 September [2024 January 15]; 293(36):13795-804. This study was published in Molecular Cell. References 1 Drouin J, Mayran A.

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