DrugBaron

FEBRUARY 16, 2021

They can exploit their exquisite specificity to carry toxic payloads to specific locations, they can mimic the binding of natural ligands to act as agonists and they can even be engineered into bispecific (or multispecific) formats to hit several targets at once. The fourth milestone in antibody discovery is just beginning to unfold.

Molecular Biology 130

Molecular Biology Small Molecule Engineering Laboratories 130

Drug Target Review

FEBRUARY 28, 2024

These include engineering the cells to express cytokines that promote their maturation and/or differentiation, and engineering drug-resistant γδ T cells that can be combined with chemotherapies, which stress cancer cells but would otherwise also deplete the T-cell population. Trends Immunol 39(6):446-459 (2018).

Therapies 105

Therapies Engineering Molecular Biology Science 105

Drug Target Review

AUGUST 29, 2024

By simultaneously deleting CD5 and expressing a CD5-targeting CAR into engineered patient T cells, VIPER-101 offers a novel approach for treating T-cell lymphoma. Can you explain the key features and benefits of the Senza5 platform developed by Vittoria Biotherapeutics?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

The Pharma Data

NOVEMBER 22, 2021

State-of-the-art R&D facility designed to foster collaboration across world-class science ecosystem Sustainable environmental engineering aligned to Company’s zero carbon future. This enhancement moves AstraZeneca well above the current assiduity average success rate of 14 in the 2018-2020 timeframe.4.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

Codon

JUNE 18, 2024

When these engineered cells are then placed into a mouse, one can use ultrasound to “hear” the cells as they move around. One can even explode the gas vesicles using high pressure soundwaves, akin to molecular warheads, with astounding implications for medicine. coli cell that had been engineered to express gas vesicles.

Engineering 66

Engineering Laboratories International Clinical Trials 66

Drug Target Review

FEBRUARY 15, 2024

Advances in molecular biology have led to highly safe, efficient, and effective platforms, such as mRNA, that can be rapidly re-purposed for different pathogens, multiple pathogens, or new strains of evolving pathogens. 2023 May 12; Available from: [link] National Academies of Sciences, Engineering, and Medicine. Office USGA.

Drug Development 122

Drug Development Virus Vaccine Government 122

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Journal of Molecular Biology (1961).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97