Broad Institute

JANUARY 14, 2025

In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration. His lab had just developed base editing, a gene-editing approach that makes single-letter changes in DNA and can shut down protein production using strategies including installing a stop signal in the genetic code.

Disease 144

Disease DNA Protein Production Treatment 144

Drug Target Review

JULY 5, 2023

There will also likely be a need to utilise a directed evolution approach and/or cell line engineering to enhance the desired growth and productivity characteristics, and stages such as cell banking, adventitious agent testing and cell line history preparation can be required. 2018) 34(6): 1460-1471. Wang B, Albanetti T, et al.

Engineering 105

Engineering DNA Laboratories Production 105

The Pharma Data

MARCH 23, 2022

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. . “The virus hijacks this protein and makes it do something different than its normal job in cells.

Virus 52

Virus Small Molecule Protein Production Research 52

Drug Target Review

DECEMBER 10, 2024

Alexandra (Alex) Bonnyman, Director of Engineering Operations at Sunflower Therapeutics , is driving innovation in protein manufacturing while advocating for greater inclusion of women in STEM. Alex earned her MS in Technology Management from Wentworth Institute of Technology in 2018.

Protein Production 98

Protein Production Production Engineering Vaccine 98

Codon

AUGUST 10, 2023

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Artificial Life (2018). Nature Biotechnology (2018). Science (2018). Nature (2005).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97

Codon

AUGUST 10, 2023

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Artificial Life (2018). Nature Biotechnology (2018). Journal of Biological Engineering (2010).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52