2018 Engineering Small Molecule 
DrugBaron
FEBRUARY 16, 2021
Small molecules are well-suited to inhibiting enzymes, such as kinases or proteases, but they struggle to block protein:protein interactions. Winter, together with George Smith and Frances Arnold, was also duly recognised with a Nobel Prize for this work in 2018. And many times, we don’t do a very good job even still.
Drug Target Review
JULY 13, 2023
Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field. They found that although the targets themselves may not be easily druggable due to their disordered nature, their ability to condense can be modulated using small molecules.
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The Pharma Data
DECEMBER 17, 2020
Kurtz brings more than 26 years of experience in global manufacturing, engineering, supply chain, CMC development and program management for drugs and devices at various stages of development. Prior to Aktana, Daveynis served as vice president of engineering at Verint and held prior leadership roles at Capsilon, Quantros, HP, and Kodak.
The Pharma Data
MARCH 23, 2022
Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. In fact, antiviral therapies designed to treat viruses such as hepatitis C (Sofosbuvir/SOVALDI) work by blocking viral polymerase.
New Drug Approvals
SEPTEMBER 13, 2024
30 January 2018. “LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders” Neuropharmacology. Reed B, Butelman ER, Fry RS, Kimani R, Kreek MJ (March 2018). McHugh KL, Kelly JP (2018).
The Pharma Data
OCTOBER 14, 2020
2018) PLoS One. Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing small molecules and biologics to treat and prevent human disease and alleviate suffering. Horsepox and vaccinia are closely related orthopoxviruses that are believed to share a common ancestor.
Dark Matter Blog
AUGUST 27, 2020
A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. We have overcome many obstacles on this mission, inventing new concepts and methods where necessary and re-engineering known concepts and methods where possible.
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