Drug Discovery World

APRIL 22, 2024

The treatment becomes only the second CAR-T cell therapy to secure routine funding for use in the NHS, and the only one for treating ALL in children and young adults under 26 years old.

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Drug Discovery World

DECEMBER 18, 2023

Casgevy The committee recommended granting a conditional marketing authorisation for Casgevy (exagamglogene autotemcel), an advanced therapy medicinal product (ATMP) for the treatment of transfusion dependent beta-thalassemia and severe sickle cell disease.

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Drug Target Review

NOVEMBER 7, 2023

To test which patients are more likely to respond to LYTAC therapy, the level of neddylated CUL3 could be measured. Enzyme replacement therapy is a frequent treatment for these disorders. 2018 December [2023 November 1]; 6(24):476. The team also found proteins that block LYTACs from functioning normally. References 1 Sun A.

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A Dose of Drug Development

SEPTEMBER 17, 2018

By: Kevin Cho Despite market volatility, 2018 has been on an astounding year for the biotech companies. How Integrium as a company plays a role in advanced technology such as these is that Integrium has the advantage of having 20 years of experience with variety of therapies within its portfolio. BIL and the year is yet to be over.

Marketing 40

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Drug Discovery World

JULY 14, 2022

Pharmaceutical company SIGA Technologies has announced that its oral therapy tecovirimat has been approved in the UK for the treatment of smallpox, monkeypox, cowpox. . The therapy has also been approved for the treatment of complications following vaccination against smallpox in adults and children with a body weight of at least 13kg. .

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Drug Discovery World

SEPTEMBER 15, 2022

A new combination therapy could represent a significant advancement in the treatment of metastatic colorectal cancer. CRC is the second most common cause of cancer mortality, accounting for 881,000 deaths globally in 2018, and patients with metastatic disease have a five-year survival rate of just 11%.

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Drug Discovery World

JUNE 14, 2023

After reviewing results of the DESTINY-Breast04 trial and other studies, the CAP/ASCO panel determined that the current HER2 testing recommendations remain valid to identify all breast cancer patients who might benefit from the full spectrum of HER2 related therapies.

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Protein Expression Clinical Trials Trials Laboratories 130

Drug Discovery World

SEPTEMBER 1, 2023

metaLead, which is developing therapies to treat metal-related diseases, currently focused on Wilson disease, lead poisoning, and neurodegeneration with brain iron accumulation. Since its inception in 2018, BII has supported 87 start-ups and projects.

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Laboratories Disease Therapies Treatment 130

Drug Discovery World

MAY 22, 2023

Cell therapy, RNA technology, antibody drug conjugates and AI/machine learning are among the key areas of investment for pharma, according to a new report. While the reported bio partnering deal values for 2022 were the second highest recorded, the number of transactions was the lowest since 2018. Biotech companies raised $16.9

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Antidote

JULY 29, 2022

Between 2009 and 2018, U.S. billion to bring a new therapy to market. The process of getting a new drug to market is an expensive one. biopharmaceutical companies spent about $1 billion per drug according to an analysis published in JAMA , and other studies have found that it can cost up to $2.8

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Drug Discovery World

DECEMBER 13, 2022

The therapy, known as a bispecific antibody, binds to both T cells and multiple myeloma cells and directs the T cells to kill multiple myeloma cells. The success of talquetamab was even seen in patients whose cancer was resistant to all approved multiple myeloma therapies. Talquetamab was tested in Phase I and Phase II trials.

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Drug Discovery World

APRIL 11, 2023

2018; 10 (1): 34‐45 Duchesne M, et al. 2018; 200: 2253–2262. The National Institute for Health and Care Excellence (NICE) has issued final draft guidance recommending AstraZeneca’s Tezspire (tezepelumab). International ERS/ATS guidelines on definition, evaluation, and treatment of severe asthma. Eur Respir J. 2014;43:343-373.

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Treatment Clinical Trials Trials Science 246

The Pharma Data

DECEMBER 22, 2020

Tagrisso Approved as Adjuvant Therapy for NSCLC With EGFR Mutations. Tagrisso was approved in 2018 for first-line treatment of patients with metastatic non-small cell lung cancer with EGFR exon 19 deletions or exon 21 L858R mutations. Professional. TUESDAY, Dec. Food and Drug Administration announced Friday.

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Therapies FDA Treatment Disease 52

Drug Discovery World

MAY 15, 2024

Dr Catherine Beech , CEO at Exonate and Dr Pete Adamson , CSO at Breye Therapeutics discuss the need for better therapies to treat diabetic retinal disease and current progress in the field. Selective targeting would enable the therapy to treat the disease whilst not impacting the natural processes of VEGF. Diabetes Res Clin Pract.

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Disease Treatment Therapies Pharmaceuticals 162

Drug Discovery World

DECEMBER 20, 2022

While antibodies must be injected, minibinders can be formulated as oral therapies thanks to their exceptional stability. . Since its inception in 2018, BII has supported 70 start-ups and projects with €59 million. Recent company successes include Adcendo, Stipe Therapeutics, Twelve Bio, Octarine Bio, and Cirqle Biomedical.

Laboratories 130

Laboratories Science International Therapies 130

Drug Discovery World

MAY 15, 2023

Renos Savva, Head of Innovation, Discovery Park Savva’s previous experience includes co-founding Domainex, recognised by the Financial Times in 2018 as the ‘fastest-growing drug discovery contract research organisation in Europe’, and developing and delivering the postgraduate Bio-business programme at Birkbeck University.

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Drug Discovery World

MARCH 6, 2023

METSYSTEM’s unique technology is designed to predict cancer metastasis and determine the optimal chemotherapy to treat it preventively. Amplify Therapeutics: Disease-modifying therapies for Gaucher disease and genetic subgroups of Parkinson’s disease.

Science 130

Science RNA Disease International 130

Drug Discovery World

AUGUST 10, 2022

But decades of research led to improvements in cancer therapy, centred around the idea that one’s immune system could aid in treatment. Next, the advent of antibody treatments in 1997 created the first targeted cancer therapy 2. Since 2017, five CAR T cell therapies have been approved and have shown incredible success in the clinic.

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Therapies Virus Treatment Engineering 246

Drug Discovery World

JUNE 1, 2023

A market research report published in late June 2018 by HTF market Intelligence Consulting suggested that the ADC market in China would grow exponentially by 2023 4. Varying sources suggest that China has been one to watch over recent years and continues to be going forward.

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Marketing FDA Approval Licensing Licensing 245

Drug Discovery World

JULY 22, 2022

Although immunotherapy has revolutionised cancer therapy, the effectiveness of currently available immunotherapies varies significantly across patients and treatment types. To mitigate these risks, clinicians are turning to other immunomodulators, such as cell-based therapies, bispecific antibodies, and cytokine treatments.

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Therapies Treatment Engineering Clinical Trials 130

Drug Discovery World

APRIL 30, 2024

Reece Armstrong explores the potential and future opportunities for mRNA-based therapies. For instance, consider how at the end of 2018, the mRNA therapies market was valued at $3.43 At the start of 2024, the first patients in a clinical trial investigating an mRNA cancer therapy were dosed.

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Therapies RNA Vaccine Small Molecule 130

Drug Target Review

SEPTEMBER 4, 2023

7,9 Dihydrofolate reductase-thymidylate synthase (DHFR) have been successfully exploited for the therapy of bacterial infections and other parasitic diseases such as malaria. 2018): Ubiquitin Proteasome pathway proteins as potential drug targets in parasite Trypanosoma cruzi, Scientific Reports. (8):8399. link] Ojewale Kayode (2018).

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Drug Target Review

NOVEMBER 6, 2023

2 It is this complexity that necessitates powerful, targeted combination therapies. 4, 5 More recently, new combination regimens have emerged that incorporate targeted therapies to treat a variety of blood cancers, including multiple myeloma (MM), chronic lymphocytic leukaemia (CLL) and acute myelogenous leukaemia (AML).

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Drug Target Review

DECEMBER 28, 2023

In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. However, if the therapy targets only the subclonal (branch) mutations, this will result in the mere ‘pruning’ of specific branches rather than elimination of the whole cancer.

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Bioinformatics Immune Response DNA Vaccine 104

Common Sense for Drug Policy Blog

JANUARY 5, 2024

of the US adult population, injected drugs in 2018. Much of this increase is likely attributable to increases in IDU, but it is important to consider methodological differences in the creation of this 2018 estimate vs the 2011 estimate. million PWID in 2011, which suggest the 2018 estimate is closer to 3 times higher than in 2011.

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Drugs Treatment Disease Therapies 40

Drug Target Review

JANUARY 25, 2024

The peptide in development is based on a 2018 Cleveland Clinic discovery and serves as a proof-of-concept for this type of drug for triple-negative breast cancer. 2 The cells of this cancer lack certain receptors so drugs designed to treat other subtypes of breast cancer will not work.

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Clinical Trials Treatment Science Research 105

Drug Discovery World

NOVEMBER 7, 2022

In 2018, the UK’s department of health announced an NHS Genomic Medicine Service, which allows patients with rare diseases to have their entire genetic code read in the hope of providing a much-needed diagnosis. Context . This included additional check-ups for heart problems, hearing loss, and diabetes, and access to clinical trials.” .

Disease 130

Disease Bioinformatics Laboratories DNA 130

Drug Discovery World

OCTOBER 4, 2022

“Global dementia prevalence is expected to increase to 152 million in 2050, a 204% increase compared to 2018. billion in 2013 to less than $3 billion in 2018) due to loss of patent protection for the five FDA approved pharmacologic treatments available for AD, none of which slow or stop the damage from the disease. .

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Drug Discovery World

SEPTEMBER 26, 2022

The approval by the European Commission was based on results from the Pathfinder clinical trial programme, which included the pivotal Navigator Phase III trial in which Tezspire demonstrated superiority across every primary and key secondary endpoint in patients with severe asthma, compared to placebo, when added to standard therapy.

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Common Sense for Drug Policy Blog

JUNE 6, 2024

2018 ; Llewellyn and Tober 2010; Denham 2019 ). 2017 ; Greenway and Price 2018 ). This includes users sourcing products online as self-prescribed testosterone replacement therapy (TRT) (Dunn et al. According to Turnock ( 2020 ), most anabolics steroids in the UK are produced in domestic ‘underground labs’ (UGLs) (Coomber et al.

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Marketing Drugs Production Pharmaceuticals 40

Agency IQ

NOVEMBER 3, 2023

regulatory landscape for probiotics and other microbiome-based therapies Probiotics, a type of microbiome-based therapy containing live micro-organisms, are broadly available on drug store and grocery store shelves, but the regulatory classifications for products containing the same micro-organism can differ dramatically.

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Therapies Science FDA Production 40

FDA Law Blog: Drug Discovery

DECEMBER 13, 2023

An Opportunity to Convene this New Advisory Committee for All Rare Disease Therapies In 2018, HP&M attorneys Frank Sasinowski and James Valentine proposed a Rare Disease Center of Excellence (which we blogged about here ).

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Disease Production FDA Drug Development 59

The Pharma Data

MAY 2, 2023

including Executive Vice President and Chief Financial Officer from 2018 through the company’s sale to ICON plc, and previously as Senior Vice President, Accounting and Corporate Controller from 2008 to 2018. Bonello held roles of increasing responsibility at Nasdaq-listed PRA Health Sciences, Inc., Source link: [link]

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Clinical Trials Clinical Research Science Clinical Development 40

Drug Discovery World

OCTOBER 6, 2022

France, Switzerland, and the United Kingdom have seen the fastest growth, accounting for 63% of the biotechs founded between 2018 and 2020.” France, Germany, and the United Kingdom (home to the largest biotech hub) stand out as the top three biotech centres in Europe, and together account for half of all European biotechs. Hotspots .

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Targeted Protein Degradation Drugs Pharma Companies Marketing 130

Drug Target Review

OCTOBER 11, 2023

1,2 Many, however, do have dysfunctional proteins at their core, and for these diseases, a new option is being explored: autophagy-boosting therapies. Gene therapy, of course, also holds great promise. 2018 [cited 2023 Sep 5]. Most of these conditions are genetic in origin and the majority have no effective treatment.

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Disease Treatment Small Molecule Therapies 112

Drug Discovery World

SEPTEMBER 16, 2022

Here, DDW Editor Reece Armstrong explores the global hubs of innovation for cell and gene therapies. Since the approval of Kymirah in 2017, the cell and gene therapy sector has emerged as an exciting and innovative market, representing some of the most promising drugs the pharmaceutical industry has ever seen. .

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Therapies Clinical Trials Production Trials 130

The Pharma Data

OCTOBER 29, 2020

29, 2020 — Long-term use of estrogen-only and combined estrogen and progestogen hormone replacement therapy (HRT) is associated with an increased risk for breast cancer, according to a study published online Oct. Study Updates Risks for Breast Cancer Associated With HRT. THURSDAY, Oct. 28 in The BMJ. Yana Vinogradova, Ph.D.,

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Doctors Therapies Treatment Research 52