2019 - Drug Discovery Digest

Changes to CDSCO’s Rules for Clinical Trials in India: New Drugs & Clinical Trial Rules 2019

ProRelix Research

JUNE 6, 2023

However, […] The post Changes to CDSCO’s Rules for Clinical Trials in India: New Drugs & Clinical Trial Rules 2019 appeared first on ProRelix Research. Being the second most populous country in the world with skilled labor and good infrastructure, India is a favorable destination for clinical trials for a wide variety of diseases.

Clinical Trials

Clinical Trials Trials Drugs Disease

Drug Discovery Today publishes editorial on new approaches to the discovery of novel agents against 2019-nCoV (COVID - 19)

Drug Discovery Today

MARCH 18, 2020

Drug Discovery Today has today published a pre print of an editorial by Yongtao Duan, Hai-Liang Zhu and Chongchen Zhou of Henan Provincial Key Laboratory of Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China

Laboratories

Laboratories Hospitals Drugs Disease

Tripling in proportion of smokers’ duty free tobacco purchases in England since 2019

SCIENMAG: Medicine & Health

JULY 18, 2023

The proportion of smokers’ duty free tobacco purchases in England has tripled since 2019, rising from just over 5% to just over 16%, but there’s been no reported change in black market purchases, reveals a time-trends analysis published online in the journal Tobacco Control.

Marketing

Growth in Reports of Xylazine in the US 2019-2022

Common Sense for Drug Policy Blog

JANUARY 5, 2024

Growth in Reports of Xylazine in the US 2019-2022 "In 2019, relatively low rates of xylazine NFLIS [National Forensic Laboratory Information System] reports were observed; all states had a rate below 6 xylazine NFLIS reports per 100,000 residents, and 16 states had zero NFLIS xylazine reports ( Figure 1 ; eTable 4 in Supplement 1 ).

Laboratories

Laboratories Drugs

A trial HIV vaccine triggered elusive and essential antibodies in humans

Science Daily: Pharmacology News

MAY 17, 2024

An HIV vaccine candidate triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrolled in a 2019 clinical trial.

Vaccine

Vaccine Trials Clinical Trials

Genetic tracing at the Huanan Seafood market further supports COVID animal origins

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).

Marketing

Marketing Virus Disease

Why petting your cat leads to static electricity

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

In 2019, researchers discovered nanosized surface deformations at play. Static electricity was first observed in 600 B.C., but researchers have struggled to explain how rubbing causes it. The same researchers now say different electrical charges build up on the front and back parts of a sliding object, creating a current.

Research

Flagship-backed Generate raises $273M as its first drugs move to the clinic

BioPharma Drive: Drug Pricing

SEPTEMBER 14, 2023

Since 2019, Generate has raised nearly $700 million in private financing and has now brought a monoclonal antibody into Phase 1 testing.

Drugs

Pfizer to pull sickle cell drug from market, shut down trials

BioPharma Drive: Drug Pricing

SEPTEMBER 26, 2024

The withdrawal comes as trial results indicate safety concerns with the drug, Oxbryta, which was first approved in the U.S.

Trials

Trials Marketing Drugs

Forest carbon storage has declined across much of the Western U.S., likely due to drought and fire

Science Daily: Pharmacology News

JULY 11, 2024

The paper analyzed trends in carbon storage across the American West from 2005 to 2019. But a new study confirms widespread doubts about the potential for most forests in the Western US to help curb climate change.

Astronomers see a massive black hole awaken in real time

Science Daily: Pharmacology News

JUNE 18, 2024

In late 2019 the previously unremarkable galaxy SDSS1335+0728 suddenly started shining brighter than ever before. To understand why, astronomers have used data from several space and ground-based observatories, including the European Southern Observatory's Very Large Telescope (ESO's VLT), to track how the galaxy's brightness has varied.

Flavored Vapes Behind Big Surge in U.S. E-Cigarette Sales

Drugs.com

NOVEMBER 22, 2024

22, 2024 — E-cigarettes flew off store shelves between 2019 and 2023, and 80% were in youth-friendly flavors like fruit, candy, mint and menthol.In FRIDAY, Nov. all, e-cigarette sales rose 47% over the period, according to a new report from the CDC.

Infertility Is Rising Among Young Married Women

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- The percentage of married American women under the age of 50 who are infertile rose between 2011 and 2019, new government statistics show.Data from the National Survey of Family Growth show that "the percentage of.

Government

Rates of Anxiety, Depression Rising Among Americans, Especially the Young

Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- Rates of anxiety and depression among U.S. adults, especially younger folks, continues to rise, the latest federal data shows.Nearly 1 in every 5 (18.2%) adults reported anxiety issues in 2022, up from 15.6%

Prime Editing: Adding Precision and Flexibility to CRISPR Editing

addgene Blog

DECEMBER 12, 2024

But prime editing, a CRISPR technique developed in David Lius lab in 2019, has added considerably more precision and flexibility to the CRISPR editing world. Plus, it can combine different types of edits with one another.

DNA

Americans Can Expect to Spend Half Their Lives Taking a Prescription Drug

Drugs.com

OCTOBER 18, 2023

For males born in 2019, it’s about 48% of their lives. TUESDAY, Oct. 17, 2023 -- Americans born in recent years can likely count on taking prescription drugs for about half their life, according to new research. For women, it’s 60% of.

Drugs

Drugs Research

Planetary Health Diet associated with lower risk of premature death, lower environmental impact

Science Daily: Pharmacology News

JUNE 10, 2024

This large study directly evaluates the impacts of adherence to recommendations in the landmark 2019 EAT-Lancet report. People who eat a healthy, sustainable diet may substantially lower their risk of premature death in addition to their environmental impact, according to a new study.

Research

Forests endure as carbon sink despite regional pressures

Science Daily: Pharmacology News

JULY 17, 2024

billion metric tons of carbon per year, which is nearly half of the carbon dioxide emissions from burning fossil fuels between 1990 and 2019. The study, based on long-term ground measurements combined with remote sensing data, found that forests take up an average of 3.5

Vaping Rates Fall Among Teens, But Still Too High

Drugs.com

MAY 14, 2024

of teens who vaped in 2019, a new report finds.However, the 5% vaping rate. TUESDAY, May 14, 2024 -- Vaping rates among U.S. kids in grades 9 through 12 fell to 5% in 2021, the latest year for which data is available. That's down from a peak of 7.2%

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Broad Institute

JULY 10, 2024

A three-drug cocktail known as Trikafta has greatly improved patient quality of life since its development in 2019, but can cause cataracts and liver damage and must be taken daily at a cost of about $300,000 per year.

Engineering

Engineering Packaging DNA Treatment

Emergence of SARS-CoV-2 variant JN.1 raises concerns with increased transmissibility and immune evasion

SCIENMAG: Medicine & Health

FEBRUARY 9, 2024

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a worldwide threat. The emergence of the BA.2.86 variant, a subvariant of Omicron, has raised significant concerns due to its substantial number of mutations. and […]

Bayer reports positive early data for Parkinson’s cell therapy

BioPharma Drive: Drug Pricing

AUGUST 28, 2023

The treatment, developed by a biotech Bayer acquired in 2019, appeared safe in a small trial and showed signs of an effect on disease progression.

Therapies

Therapies Trials Treatment Disease

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

Drugs.com

AUGUST 23, 2023

23, 2023 -- The number of Americans undergoing gender-affirming surgery is on the rise, new research reveals, almost tripling between 2016 and 2019 alone. WEDNESDAY, Aug. During that period, more than 48,000 patients -- about half of them between 19.

Research

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

In September 2019, a new formulation of long-acting injectable buprenorphine became available on the PBS. The introduction of long-acting injectable buprenorphine in September 2019 and policy changes during COVID-19 were associated with a sustained increase in the total number of clients accessing opioid agonist treatment for dependence.

Treatment

Treatment Community Pharmacies Pharmacy International

DrugPatentWatch reveals NIH funding for patents

Drug Patent Watch

JULY 27, 2023

Here’s a summary of a new article that used DrugPatentWatch data: NIH Funding for Patents That Contribute to Market Exclusivity of Drugs Approved 2010–2019 and the Public Interest Protections of… The post DrugPatentWatch reveals NIH funding for patents appeared first on DrugPatentWatch - Make Better Decisions.

Marketing

Marketing Drugs

U.S. Heart Disease Death Rates Have Fallen Sharply in Past 30 Years

Drugs.com

AUGUST 8, 2023

8, 2023 -- Fatal heart disease in the United States dropped about 4% a year between 1990 and 2019, but Americans need to quit smoking, drinking and overeating or those gains could be wiped out, according to new research. TUESDAY, Aug. The declining.

Disease

Disease Research

5 ways to lower clinical trial patient recruitment costs

Antidote

JULY 29, 2022

In 2019 alone, research and development spending totaled $186 billion for the global pharmaceutical industry. Between 2009 and 2018, U.S. biopharmaceutical companies spent about $1 billion per drug according to an analysis published in JAMA , and other studies have found that it can cost up to $2.8 billion to bring a new therapy to market.

Clinical Trials

Clinical Trials Trials Therapies Pharmaceuticals

Safety Culture in Healthcare Settings

NIOSH Science Blog: Drugs

SEPTEMBER 27, 2023

As of 2019, more than 18 million people, 11.5 % of the United States workforce, were employed in healthcare settings. Everyday healthcare workers face hazardous work conditions due to exposures to infectious agents and hazardous drugs and chemicals.

Drugs

The Most Engaging Decision You’ll Read All Year – Five Stars

FDA Law Blog: Biosimilars

JANUARY 15, 2024

FDA published a June 2019 guidance , which stated that manufacturers would not need to perform long-term studies or submit long-term data in PMTAs. At an October 2019 Meeting , FDA explained the application process and provided assurances that decisions would be made on each specific product in a submission—not the submission in its entirety.

FDA

FDA Production Regulations Marketing

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Department of Energy announces $4.6 million for research on public-private partnership awards to advance fusion energy

SCIENMAG: Medicine & Health

JULY 25, 2023

The awards are provided through the Innovation Network for Fusion Energy, or INFUSE, program, which was established in 2019. Department of Energy (DOE) announced $4.6 million in funding for 18 projects at national laboratories and U.S. universities.

Laboratories

Laboratories Research Science

Gilead’s CMO to depart next year

BioPharma Drive: Drug Pricing

JULY 17, 2024

Merdad Parsey joined Gilead as its chief medical officer in 2019 and has helped lead the company’s expansion into oncology, with mixed success.

Databases from the Future: What is Database Version 954?

Perficient: Drug Development

OCTOBER 16, 2023

Visual Studio installs a database instance for itself, which you can see when you pull up the SQL Server Object Explorer: You can already see from the screenshot that this is a SQL 2019 instance as it is v15. Right clicking this instance and selecting New Query will open up a new SQL command tab.

New CEO appointed for the UK’s national synchrotron, Diamond Light Source

SCIENMAG: Medicine & Health

AUGUST 9, 2023

He joins Diamond from the Canadian Light Source where he has been its Science Director since May 2019. It was today (9th August, 2023) announced that Professor Gianluigi Botton has been appointed as the new Chief Executive Officer (CEO) of Diamond Light Source, one of the world’s leading science facilities. He will take up his […]

Science

Astrophysicists capture astonishing images of gamma-ray flare from supermassive black hole M87

Science Daily: Pharmacology News

DECEMBER 13, 2024

The galaxy M87, located in the Virgo constellation, provided the first-ever photo of a black hole in 2019, when the Event Horizon Telescope captured an image of the supermassive black hole at the galaxy's center.

International

International Research

RNA: The most attractive target in recent viral diseases

Chemical Biology and Drug Design

DECEMBER 13, 2023

These strategies act by taking advantage of the weakness points of this attractive bioweapon to disable or attack it (itself), accordingly stop the entire viral reproduction, and effectively end the severe microbial infections such as the coronavirus disease 2019 (COVID-19).

RNA

RNA Disease Virus Drugs

The National Center for Complementary and Integrative Health (NCCIH) Priorities for Cannabis and Cannabinoid Research [Commentary]

ASPET

JUNE 6, 2024

In keeping with NCCIH's natural product research priorities and in recognizing this gap in knowledge, NCCIH formally launched a research program in 2019 to expand research on the potential therapeutic benefit of minor cannabinoids and terpenes for the treatment of pain.

Research

Research Production Treatment

Jazz drug for tremor fails study; Radiopharma drug developer ITM swaps CEOs

BioPharma Drive: Drug Pricing

JUNE 21, 2024

A medicine Jazz acquired in 2019 missed the goal of a Phase 2 study. Elsewhere, Vanda rejected two takeover bids and Ashibio emerged from stealth with an antibody licensed from Gilead.

Drug Development

Drug Development Licensing Licensing Drugs

Statistical analysis of war identifies the scale on which violence begets violence

SCIENMAG: Medicine & Health

AUGUST 1, 2023

Using data on violent battles in Africa between 1997 and 2019 from the Armed Conflict Event & Location Data Project, Niraj Kushwaha and Edward D. A statistical approach describes and predicts chains of related conflict events—such as wars—in time and space.

Science

Cancers, Especially Gastro Tumors, Are Rising Among Americans Under 50

Drugs.com

AUGUST 16, 2023

Breast cancer accounted for the most cases in adults under 50 between 2010 and 2019, but. WEDNESDAY, Aug. 16, 2023 -- Breast, colon and pancreatic cancer rates are increasing at concerning rates among America's young adults, a new study finds.

PRIDICT: Predicting Efficiencies of Prime Editing Guide RNAs

addgene Blog

JUNE 25, 2024

2019; Chen & Liu, 2023). Prime editing is a versatile genome editing technology that allows precise modifications of DNA (replacements, small insertions, and deletions) without introducing DNA double-strand breaks (Anzalone et al.,

DNA

DNA RNA

NIH spent $8.1B for phased clinical trials of drugs approved 2010-19, ~10% of reported industry spending

SCIENMAG: Medicine & Health

JULY 14, 2023

billion in project funding for phased clinical trials involving drugs approved by the FDA from 2010-2019, according to a new study from Bentley University’s Center for Integration of Science and Industry. BENTLEY UNIVERSITY Credit: Bentley University BENTLEY UNIVERSITY The U.S. National Institutes of Health (NIH) contributed $8.1

Clinical Trials

Clinical Trials Trials FDA Drugs

Addressing increasingly resistant drugs by infectious agents

Drug Target Review

SEPTEMBER 4, 2023

2019): CRISPR in Parasitology: Not Exactly Cut and Dried! 2019): Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis, International journal of molecular sciences. (20):1484. 2019): Biological plasticity rescues target activity in CRISPR knockouts, Nature Methods.

Drugs

Drugs RNA DNA Disease

Changing Mindsets on Hearing Disorders Associated with Work Hazards

NIOSH Science Blog: Drugs

FEBRUARY 27, 2024

The National Institute for Occupational Safety and Health’s (NIOSH) Hearing Loss Prevention Program has been an official member of the World Hearing Forum (WHF) since it was launched in 2019. The Forum was assembled by the Office of Ear and Hearing Care of the World Health Organization to promote ear and hearing care worldwide.

Changes to CDSCO’s Rules for Clinical Trials in India: New Drugs & Clinical Trial Rules 2019

Drug Discovery Today publishes editorial on new approaches to the discovery of novel agents against 2019-nCoV (COVID - 19)

Trending Sources

Tripling in proportion of smokers’ duty free tobacco purchases in England since 2019

Growth in Reports of Xylazine in the US 2019-2022

A trial HIV vaccine triggered elusive and essential antibodies in humans

Genetic tracing at the Huanan Seafood market further supports COVID animal origins

Why petting your cat leads to static electricity

Flagship-backed Generate raises $273M as its first drugs move to the clinic

Pfizer to pull sickle cell drug from market, shut down trials

Forest carbon storage has declined across much of the Western U.S., likely due to drought and fire

Astronomers see a massive black hole awaken in real time

Flavored Vapes Behind Big Surge in U.S. E-Cigarette Sales

Infertility Is Rising Among Young Married Women

Rates of Anxiety, Depression Rising Among Americans, Especially the Young

Prime Editing: Adding Precision and Flexibility to CRISPR Editing

Americans Can Expect to Spend Half Their Lives Taking a Prescription Drug

Planetary Health Diet associated with lower risk of premature death, lower environmental impact

Forests endure as carbon sink despite regional pressures

Vaping Rates Fall Among Teens, But Still Too High

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Emergence of SARS-CoV-2 variant JN.1 raises concerns with increased transmissibility and immune evasion

Bayer reports positive early data for Parkinson’s cell therapy

U.S. Gender-Affirming Surgeries Nearly Tripled in 3 Years

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

DrugPatentWatch reveals NIH funding for patents

U.S. Heart Disease Death Rates Have Fallen Sharply in Past 30 Years

5 ways to lower clinical trial patient recruitment costs

Safety Culture in Healthcare Settings

The Most Engaging Decision You’ll Read All Year – Five Stars

TBD

Department of Energy announces $4.6 million for research on public-private partnership awards to advance fusion energy

Gilead’s CMO to depart next year

Databases from the Future: What is Database Version 954?

New CEO appointed for the UK’s national synchrotron, Diamond Light Source

Astrophysicists capture astonishing images of gamma-ray flare from supermassive black hole M87

RNA: The most attractive target in recent viral diseases

The National Center for Complementary and Integrative Health (NCCIH) Priorities for Cannabis and Cannabinoid Research [Commentary]

Jazz drug for tremor fails study; Radiopharma drug developer ITM swaps CEOs

Statistical analysis of war identifies the scale on which violence begets violence

Cancers, Especially Gastro Tumors, Are Rising Among Americans Under 50

PRIDICT: Predicting Efficiencies of Prime Editing Guide RNAs

NIH spent $8.1B for phased clinical trials of drugs approved 2010-19, ~10% of reported industry spending

Addressing increasingly resistant drugs by infectious agents

Changing Mindsets on Hearing Disorders Associated with Work Hazards

Stay Connected