Drug Discovery World

JULY 2, 2024

The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM).

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Drugs.com

AUGUST 8, 2023

8, 2023 -- Fatal heart disease in the United States dropped about 4% a year between 1990 and 2019, but Americans need to quit smoking, drinking and overeating or those gains could be wiped out, according to new research. TUESDAY, Aug. The declining.

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The Pharma Data

NOVEMBER 12, 2020

Measles surged worldwide in 2019 reaching highest number of reported cases in 23 years. Global measles deaths climbed nearly 50 percent since 2016, claiming an estimated 207,500 lives in 2019 alone. . After steady global progress from 2010 to 2016, the number of reported measles cases climbed progressively to 2019.

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The Pharma Data

DECEMBER 11, 2020

11, 2020 — From 1990 to 2019, there was an increase in the burden of cardiovascular disease (CVD) globally, according to a study published online Dec. The researchers found that prevalent cases of total CVD increased from 271 million in 1990 to 523 million in 2019, and the number of CVD deaths increased from 12.1

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Elrig

APRIL 11, 2024

One of the great highlights of a:head’s work has been the ability to observe disease-specific phenotypes and profile clinically used therapeutics for their ability to alter neuronal network activity. The post How to develop drugs for neurological diseases | Insights from Josh Bagley first appeared on ELRIG.

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The Pharma Data

DECEMBER 22, 2020

population increased in 2019, while the rate of drug overdose deaths increased from 2018 to 2019, according to two December data briefs published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics. population in 2019, an increase of 0.1 TUESDAY, Dec. years for the U.S.

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The Pharma Data

NOVEMBER 25, 2020

2016 to 2019 Saw Increase in Prepregnancy Obesity in U.S. 25, 2020 — From 2016 to 2019, there was an increase in prepregnancy obesity in the United States, according to a November data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics. percent in 2019).

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The Pharma Data

MAY 27, 2022

billion in Medicare funds in 2019 on drugs whose clinical benefits have yet to be confirmed by the Food and Drug Administration, a new study led by researchers from the Johns Hopkins Bloomberg School of Public Health suggests. billion on 36 of these drugs across 55 indications in 2019. federal government spent an estimated $1.8

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The Pharma Data

DECEMBER 22, 2020

22, 2020 — Before the COVID-19 pandemic hit, life expectancy in the United States rose in 2019 for the second year in a row, according to two new federal government reports. That would be a new record and represent 400,000 more deaths than were recorded for 2019. Centers for Disease Control and Prevention. TUESDAY, Dec.

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Drug Discovery World

MAY 20, 2024

BenevolentAI’s strategic collaboration with AstraZeneca began in 2019, and originally focused on discovering potential new treatments for idiopathic pulmonary fibrosis (IPF) and chronic kidney disease (CKD). The collaboration was expanded in January 2022 to two new disease areas, heart failure and systemic lupus erythematosus (SLE).

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The Pharma Data

JANUARY 21, 2021

Percent of Kindergarteners Not Up to Date With MMR in 2019-2020. percent of kindergarteners were not up to date with measles, mumps, and rubella (MMR) vaccination and did not have an exemption in the 2019 to 2020 school year, according to research published in the Jan. Professional. THURSDAY, Jan. 21, 2021 — Overall, 2.3

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The Pharma Data

NOVEMBER 4, 2020

Adults Had Chronic Pain in 2019. 4, 2020 — In 2019, more than 20 percent of U.S. Centers for Disease Control and Prevention National Center for Health Statistics. percent of adults had chronic pain in 2019, and 7.4 Professional. Percent of U.S. WEDNESDAY, Nov. Zelaya, Ph.D., Zelaya, Ph.D.,

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SCIENMAG: Medicine & Health

AUGUST 15, 2023

. — Exposure to environmental chemicals, including those in common plastic products, has been linked with an increased risk of cardiovascular disease, or CVD, the leading cause of death worldwide. million people died from CVDs in 2019. According to the World Health Organization, 17.9

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Drug Target Review

JUNE 21, 2023

Most rare diseases are caused by a single gene defect, but severity can vary considerably among patients. Modifier genes can help explain that variability and can alter or even prevent disease onset and progression, making them appealing therapeutic targets. However, the identification of these genes is challenging.

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SCIENMAG: Medicine & Health

JUNE 8, 2023

Statement Highlights: A new American Heart Association scientific statement focuses on treatment strategies for pediatric cardiomyopathy (diseases of the heart muscle’s structure and function that may lead to heart failure and death) and is a companion to a 2019 scientific statement focused on diagnosis of the condition.

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Creative Biolabs

JANUARY 15, 2020

By understanding the mechanism of new product development, product screening and production processes, as well as the diseases and symptoms that drugs need to treat, CDER provides scientific and regulatory advices for products that are about to be brought to market.

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Clinical Trials FDA Trials Drugs 52

Drug Discovery Today

MARCH 18, 2020

Drug Discovery Today has today published a pre print of an editorial by Yongtao Duan, Hai-Liang Zhu and Chongchen Zhou of Henan Provincial Key Laboratory of Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China

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Drug Discovery World

FEBRUARY 20, 2024

With capacity for up to 60 research scientists and employees, the company says the site will play a role in helping to drive innovation in the UK life sciences sector, with the ambition of bringing forward new medicines for patients living with inflammatory diseases. Gilead acquired MiroBio, an Oxford-backed research company, in 2022.

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Drug Target Review

MAY 18, 2023

In sickle cell disease, however, this function is impaired, leading to a range of potential health consequences. The irregularly shaped and sticky red blood cells produced by the disease can obstruct small blood vessels, causing recurring painful attacks. Hydroxyurea, the first sickle cell drug approved by the U.S.

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Drug Discovery World

FEBRUARY 8, 2023

A diversity study has shown that clinical trials should use real world diseases epidemiology data, rather than US Census Bureau race and ethnicity data, to ensure enrolment reflects the populations affected by different diseases. For example, US Census Bureau data indicates 13.4%

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The Pharma Data

DECEMBER 9, 2020

10, 2020 — Heart disease is the leading cause of death worldwide — accounting for one-third of deaths in 2019 — and the death toll continues to rise, a new paper says. China had the highest number of heart disease deaths last year, followed by India, Russia, the United States and Indonesia. WEDNESDAY, Dec.

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Broad Institute

SEPTEMBER 15, 2023

We apply STACI to analyze the spatio-temporal progression of Alzheimer’s disease and identify the associated nuclear morphometric and coupled gene expression features.

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Disease 40

The Pharma Data

JANUARY 12, 2021

12, 2021 — During the initial phase of the COVID-19 pandemic, there was an increase in deaths caused by ischemic heart disease and hypertensive diseases in the United States, as well as a reduction in cardiovascular diagnostic testing across the world, according to two studies published in the Jan. TUESDAY, Jan. Einstein, M.D.,

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The Pharma Data

JANUARY 27, 2021

27, 2021 — Heart disease remains the leading cause of death worldwide, with 18.6 million deaths attributed to cardiovascular disease (CVD) globally in 2019, according to a report from the American Heart Association published online Jan. According to the report, in 2019, about 18.6 WEDNESDAY, Jan. 27 in Circulation.

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Drug Discovery World

OCTOBER 16, 2023

University College London (UCL) spinout AstronauTx has closed a £48m ($61m) Series A financing to develop novel treatments for Alzheimer’s disease and other neurodegenerative disorders. The company was launched in 2019, initially to build on research from the Alzheimer’s Research UK UCL Drug Discovery Institute (UCL DDI).

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Advarra

AUGUST 16, 2022

A rare, or orphan, disease by definition affects a small percentage of the population — fewer than 200,000 people in the U.S. But the numbers add up, and taken together, rare diseases impact an estimated 30 million Americans. Since then, the FDA has significantly changed its approach to rare and orphan diseases.

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Drug Discovery World

NOVEMBER 13, 2023

Genome sequencing has been used to study typhoid fever in a study in Zimbabwe and understand how the disease has evolved to be resistant to treatment. In response, an emergency reactive vaccination campaign using Typhoid Conjugate Vaccine (TCV) was initiated in suburbs of Harare in 2019, providing moderate protection. Typhi strains.

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Advarra

AUGUST 10, 2023

Rapid growth in gene therapy is expected to receive additional support as the Food and Drug Administration (FDA) Center for Biologics Evaluation and Research (CBER) prepares to launch Operation Warp Speed for Rare Diseases. Now, FDA’s CBER is setting its sights on making ambitious strides toward tackling rare diseases.

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Drug Discovery World

JANUARY 2, 2024

A promising treatment option, JAK inhibitors act by blocking the JAK family kinases and inhibiting the inflammatory pathways involved in AD and other inflammatory diseases. They reviewed the available safety data and analysed the risk of 11 adverse events from 14 RCTs published between 2019 and 2022.

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BioPharma Drive: Drug Pricing

AUGUST 28, 2023

The treatment, developed by a biotech Bayer acquired in 2019, appeared safe in a small trial and showed signs of an effect on disease progression.

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Drug Discovery World

FEBRUARY 3, 2023

A research group from the National Institutes of Health has successfully developed a vaccine against Sudan virus (SUDV) based on the licensed Ebola virus (EBOV) vaccine. SUDV, identified in 1976, is one of the four viruses known to cause human Ebolavirus disease. The findings were published in the journal The Lancet Microbe.

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Drug Discovery World

JULY 15, 2022

Pharmaceutical company Transpire Bio will work alongside drug delivery provider Recipharm to develop two inhaled medicines for the treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD).? . Asthma is thought to affect over 300 million people and in 2019 caused 455,000 deaths 1. million people dying from the condition.

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Drug Discovery World

JULY 8, 2022

Immutep is looking to use IMP761 to address the root cause of autoimmune disease through its function to silence autoimmune memory T cells that accumulate at the disease site and which express LAG-3 as an “exhaustion marker. . 1 More so, follow up studies in 2021 show that IMP761 decreased effector T cell cytokine secretion.

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Drug Discovery World

SEPTEMBER 22, 2022

Pfizer will make a $20 million equity investment, have options to license CytoReason’s platform and disease models, and fund supplementary project support. CytoReason’s platform has reportedly provided Pfizer with insights in research and development programs across over 20 diseases. .

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Drug Discovery World

FEBRUARY 12, 2024

Set against the backdrop of the awe-inspiring technological advances that we hear about on an almost daily basis, I can’t help feeling shocked that we have so little to offer people with strokes, dementia, most cancers, brain injuries, multiple sclerosis, motor neurone disease, osteoarthritis, Crohn’s disease, Parkinson’s disease … the list goes on.

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Drug Discovery World

NOVEMBER 1, 2022

Its snapshot report aimed to provide both an overview of the sector in Australia to determine how the sector has changed since this data was collected in 2017 and 2019 2. . The number of employees behind our biotech companies has also expanded, increasing 21% compared with 2019 from approximately 87,397 people in 2019 to 105,569 in 2022.

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Drug Discovery World

SEPTEMBER 14, 2023

N Engl J Med 2019; 381(4):338-348. Europe has one of the highest rates of bladder cancer in the world 1 , with more than 203,000 patients diagnosed in 2020 alone 2. Patients with mUC, including FGFR-driven tumours, face a particularly poor prognosis and the need for innovative therapies remains high. Fernandez E, et al. J Clin Med.

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