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Bayer gets go-ahead for Huntington’s Disease gene therapy trial  

Drug Discovery World

A Phase I/II clinical trial targeting a treatment for Huntington’s Disease (HD) using a gene therapy has been given the clearance to go ahead in France. . In 2019, BV-101 was granted orphan drug designation in the European Union. . In 2019, BV-101 was granted orphan drug designation in the European Union. .

Therapies 246
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Diabetic eye disease: The urgent need for early, non-invasive treatments

Drug Discovery World

Dr Catherine Beech , CEO at Exonate and Dr Pete Adamson , CSO at Breye Therapeutics discuss the need for better therapies to treat diabetic retinal disease and current progress in the field. Diabetic retinopathy – current treatments The journey for patients with DR is one of increasing severity and loss of vision.

Disease 163
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How to advance AAV-based gene therapies

Drug Discovery World

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas.

Therapies 163
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Concussion drug therapies on the horizon

Drug Discovery World

Over the past 20 years research has increasingly linked concussions to neurogenerative conditions, including dementia, Alzheimer’s disease and CTE, a degenerative brain disease. More than 413,000 service members were diagnosed with a TBI between 2000 and Q3 of 2019. Over 80% of these were concussions.

Therapies 148
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Janssen submits EMA filing for bladder cancer treatment 

Drug Discovery World

6,7 “For patients with advanced UC, including FGFR-driven tumours, outcomes remain poor and treatment options are limited; therefore, there is a need for novel, targeted therapies,” said Martin Vogel, EMEA Therapeutic Area Lead Oncology, Janssen-Cilag GmbH.

Treatment 130
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Can an antibody therapy prevent fentanyl overdoses?

Drug Discovery World

DDW Editor Reece Armstrong speaks to Tracy M Woody , President and Chief Executive Officer of Cessation Therapeutics, about the company’s goal to develop an antibody therapy to prevent fentanyl overdoses. TW : Narcan (or naloxone) is a very important treatment for fentanyl overdose. Yet opioid deaths are high in the US.

Therapies 148
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Add-on treatment for severe uncontrolled asthma approved 

Drug Discovery World

Owing to the complexity of severe asthma, many patients have unclear or multiple drivers of airway inflammation resulting in some patients not responding to the current standard of treatment, and being at increased risk of asthma attacks, hospitalisations, and a poor quality of life 3,4,5,6. 2019 May 23;380(21):2082]. 2005;172:149-160.

Treatment 246