Broad Institute

NOVEMBER 13, 2023

This commitment to the Gerstner Center for Cancer Diagnostics includes $10 million for current support for the Center and $10 million in endowed funding, adding to the $15 million originally committed by Gerstner and an initial endowment of $10 million from the Eli & Edythe Broad Foundation to establish the Center in 2019.

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PLOS: DNA Science

SEPTEMBER 7, 2023

As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. Train an algorithm on the DNA sequences of a known disease-causing gene, then search for identical or highly similar sequences in cells from other individuals to assist diagnosis.

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PLOS: DNA Science

MAY 16, 2024

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. ” I’ve long thought that SARS-CoV-2, or an immediate viral predecessor, emerged years before 2019 – at least as far back as 2013. appeared first on DNA Science. • Single-cell sequencing.

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Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. PE 740.238 Bryant, M. Sebastian, B., Adriana, T.,

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Drugs RNA DNA Disease 111

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

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PLOS: DNA Science

JUNE 27, 2024

The animals also tolerated conditions aboard the International Space Station in 2011, and seemed to have survived a crash into the moon from a probe in 2019. After all, they can reproduce even under radiation levels 1,000 times that which would kill a human, possessing admirable DNA repair skills.

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PLOS: DNA Science

OCTOBER 19, 2023

Last week DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). It aims to correct the faulty instructions at the DNA level, straightforward, at least conceptually, because mutations are deletions, of part or all of the gene. That’s not the case for ALS.

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PLOS: DNA Science

OCTOBER 5, 2023

Amy in June 2019. Bess’s mom died of BC in October, 2019. And Tobie was just diagnosed, late 2019. The post How Breast Cancer Reunited Six High School Friends appeared first on DNA Science. For what it’s worth, our school’s history wasn’t always something to be proud of. Wendy in late 2018.

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The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. Cancers 11 , 394 (2019). 161 , 416–432 (2019). 23 , 4854–4865 (2019). & Ohi, R.) 403–421 (Springer, 2016). Fu Y, Ho M.

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Codon

DECEMBER 12, 2024

This includes recipients of a three-million-dollar grant , awarded by the National Science Foundation in 2019, to “design, construct, and safely deploy synthetic mirror cells.” DNA and RNA molecules are also built from exclusively right-handed nucleic acids. 4 As far as we know, right-handed proteins never occur naturally.

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DNA RNA Vaccine Virus 104

Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. DNA-encoded antiviral proteins delivered to the nose or lungs of mice have previously been shown to protect against influenza or COVID-19.

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RNA Virus DNA Vaccine 102

Broad Institute

DECEMBER 13, 2023

One cell at a time Slide-seq, reported in 2019 , involves transferring slices of tissue onto arrays of special beads, each one tagged with a DNA barcode that identifies its location in the array.

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Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. That paper changed hearts and minds,” Neale, a co-author, said of the 2019 paper in Nature Genetics.

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Disease Bioinformatics Medical Schools Research 98

Drug Target Review

APRIL 26, 2023

Gene-editing methods allow researchers to modify DNA, resulting in alterations in physical characteristics such as eye colour and susceptibility to diseases. To achieve this, scientists utilise various technologies that function similarly to scissors, precisely cutting the DNA at a particular location.

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Drug Target Review

OCTOBER 12, 2023

Prime editing, a pioneering genome editing technique, was applied, enabling the scientists to introduce a single DNA base substitution at a time and to assess individual variant function at the TSPAN14 AD risk locus. 2019 August 30 [cited 2023 October 6]; 11(233):20. References Hemonnot AL, Hirbec H, Hua J, Ulmann L.

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New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. and Europe.

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Small Molecule DNA Disease Trials 62

Drug Target Review

JUNE 9, 2023

Adaptive Biotechnologies and Genentech entered a partnership in 2019 to develop, manufacture and commercialise novel neoantigen directed T-cell therapies for the treatment of a broad range of cancers. While tumour cells share a majority of their DNA with healthy cells, they also carry numerous unique mutations.

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Drug Target Review

DECEMBER 4, 2023

2019 May 29;20(1). Upstart Element ratchets up race for cheaper DNA sequencing with a $200 genome [Internet]. Available from: [link] Navarro FCP, Mohsen H, Yan C, et al. Genomics and data science: an application within an umbrella. Genome Biology [Internet]. Available from: [link] Wosen J. 2023 [cited 2023 Nov 15].

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PLOS: DNA Science

OCTOBER 12, 2023

Consider Zolgensma , a gene therapy approved in 2019 to treat spinal muscular atrophy. million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. appeared first on DNA Science. Affected children rarely live past infancy. Muscles stop working.

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Therapies Immune Response DNA Virus 69

DrugBank

NOVEMBER 4, 2024

A study from Oxford University demonstrated that in 2019, 1.27 Their joint efforts have led to the development of gepotidacin , a novel first-in-class antibiotic that inhibits the bacterial enzymes topoisomerase II and DNA gyrase, which are essential for DNA replication and repair. million deaths associated with it.

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PLOS: DNA Science

MARCH 7, 2024

The researchers searched the DNA of humans and other primates for clues to how we lost our tails. They discovered that a bit of repetitious DNA, called an Alu sequence, inserted into a gene associated with tail development early in the ape lineage. ” The post How the Human Lost Its Tail appeared first on DNA Science.

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Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus.

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Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Nature reviews Drug discovery 18 , 358-378 (2019). 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases.

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PLOS: DNA Science

APRIL 18, 2024

Gene #1: The Famous Case of Aliria from the Colombian Family In 2019. ” The post Mutations in Three Genes Protect Against Alzheimer’s appeared first on DNA Science. Rare variants of three well-studied genes appear to delay inherited forms of Alzheimer’s disease – by decades.

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Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. The findings could one day help monitor the emergence of new drug-resistant threats or highlight possible ways to prevent or treat those infections.

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Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering Therapies RNA 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death.

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The Pharma Data

OCTOBER 18, 2020

(NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. Telomeres are “caps” at the end of chromosomes that protect DNA from getting worn away as cells replicate.

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DNA Molecular Biology Disease Trials 52

The Pharma Data

AUGUST 27, 2020

Cancer is a disease of the genome, driven by genetic mutations within a tumour’s DNA. FoundationOne Liquid CDx analyses circulating cell-free DNA from a patient’s blood sample and uses massively parallel sequencing to detect the four main classes of genomic alterations. In 2019, Roche invested CHF 11.7

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The Pharma Data

JANUARY 5, 2021

So therapeutics that focus on RNA are designed to stop the DNA from coding for disease-causing proteins. On September 30, 2019, Ribometrix signed a strategic collaboration deal with Boston’s Vertex Pharmaceuticals. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins.

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RNA Small Molecule DNA Licensing 52

Codon

OCTOBER 13, 2024

The chefs at Farma know that by embracing food technologies such as recombinant DNA, precision fermentation, and cell culture, food can become more nutritious and better for the planet. Since its doors opened to the public a few weeks ago, Farma has crusaded against the apocryphal purity of organic foods.

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Engineering Virus Production DNA 101

The Pharma Data

FEBRUARY 25, 2021

In March 2019, Merck Animal Health invested in Poultry Sense Ltd., In December 2019, the company acquired Vaki, a leader in fish farming and wild fish conservation monitoring equipment and real-time video monitoring technology to advance fish health and welfare. Kenilworth, N.J., from its founding shareholders. Poultry Sense Ltd.

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Vaccine Production International Disease 52

The Pharma Data

MAY 18, 2021

1 Many times, melanoma is caused by damage to the DNA in skin cells. 1 This damage to the DNA (often called a gene mutation) can cause cancerous tumors to form in the skin. Melanoma is the most serious and life-threatening type of skin cancer, but it is almost always treatable when caught early. “Be an advocate for yourself.

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Nurses Doctors DNA Treatment 52

The Pharma Data

DECEMBER 2, 2020

Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of an E. The FMv8 protocol introduces a needle-aspirate-based, cell-resuspension step prior to cell lysis that boosts DNA recovery. The Phase IIb induction study in patients with moderate-to-severe UC, enrolled the first patient in August 2019.

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Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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