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Metabolism of five membered nitrogen containing heterocycles

Metabolite Tales Blog

2019, 14, 2, 142–16 [link] 10 Chem. 1990, 1034, 233-237 [link] 13 Metabolism of pyrazole in the Rat [link] 14 Drug Metab. 2010, 75, 9, 3141–3143 [link] 22 Clin Pharmacokinet. 2000, 2, 195-201 [link] 6 Biochem. 1966 98, 266-277 [link] 7 Metabolites. 2023, 13, 1, 92- [link] 8 J. 2018, 61, 5, 2041–205 [link] 9 ACS Chem.

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Metabolism of 2022 FDA approved small molecule drugs PART 2

Metabolite Tales Blog

Deuteration at this position was found to block generation of a less selective primary amide metabolite in vivo and increase metabolic stability. Drug metabolism in drug discovery and development. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.