Metabolism of 2022 FDA approved small molecule drugs PART 2
Metabolite Tales Blog
APRIL 4, 2023
Deuteration at this position was found to block generation of a less selective primary amide metabolite in vivo and increase metabolic stability. Drug metabolism in drug discovery and development. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.
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