Broad Institute

AUGUST 31, 2023

Prime editing can make targeted insertions, deletions and other changes to DNA, and was first described in 2019 by the lab of David Liu , core institute member, Richard Merkin Professor, and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute.

DNA 145

DNA RNA Engineering Laboratories 145

Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

Small Molecule 52

Small Molecule RNA Clinical Trials Drugs 52

Broad Institute

DECEMBER 13, 2023

typeof="foaf:Image" /> New tool uses RNA sequencing to chart rich maps of cellular and tissue function When a scientist wants to study individual cells at the molecular level within an organ like the heart or brain, they usually break the tissue up to analyze the cells. However, some beads capture the RNA of multiple cells at once.

RNA 145

RNA Research DNA Hospitals 145

Drug Target Review

SEPTEMBER 4, 2023

I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 2019): CRISPR in Parasitology: Not Exactly Cut and Dried! 2019): Biological plasticity rescues target activity in CRISPR knockouts, Nature Methods. PE 740.238 Bryant, M. Sebastian, B., Sebastian, H.

Drugs 111

Drugs RNA DNA Disease 111

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

RNA 98

RNA Medical Schools Engineering Disease 98

Broad Institute

AUGUST 31, 2023

Our results show that GRouNdGAN is a stable, realistic, and effective simulator with various applications in single-cell RNA-seq analysis.

RNA 40

RNA Regulations 40

Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. Other efforts to build broad-spectrum antivirals have focused on another conserved feature of viruses: double-stranded RNA.

RNA 97

RNA Virus DNA Vaccine 97

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA 128

DNA RNA Disease Hospitals 128

PLOS: DNA Science

MAY 16, 2024

” I’ve long thought that SARS-CoV-2, or an immediate viral predecessor, emerged years before 2019 – at least as far back as 2013. As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests.

Virus 98

Virus DNA RNA Science 98

Drug Target Review

AUGUST 9, 2023

14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts. Many potential toxic effects have been suggested, including the mis-splicing of the Stathmin-2 RNA transcript. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.” Neuron vol.

RNA 98

RNA Regulations Disease DNA 98

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines. I wasnt trained at MIT, and I had never lived in Boston before.

RNA 52

RNA DNA Science Vaccine 52

Codon

DECEMBER 12, 2024

This includes recipients of a three-million-dollar grant , awarded by the National Science Foundation in 2019, to “design, construct, and safely deploy synthetic mirror cells.” DNA and RNA molecules are also built from exclusively right-handed nucleic acids. 4 As far as we know, right-handed proteins never occur naturally.

RNA 102

RNA DNA Vaccine Virus 102

The Pharma Data

JANUARY 19, 2021

In the paper, researchers from Johns Hopkins University and elsewhere found a natural long-form transactivating CRISPR RNA (tracr-L) in Streptococcus pyogenes that functions to downregulate its endogenous CRISPR-Cas9 system. But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts.

Research 52

Research RNA Molecular Biology Small Molecule 52

Broad Institute

JANUARY 30, 2024

An analysis estimated that nearly 5 million deaths in 2019 were associated with bacterial resistance to antimicrobial medicines, including 1.27 In 2019, Bhattacharyya launched his own lab at the Broad, but just as his research was picking up speed, a new threat emerged that would soon overshadow his clinical, scientific, and personal life.

Hospitals 137

Hospitals Virus Medical Schools Science 137

Broad Institute

MARCH 5, 2024

In this talk, we are motivated by unsupervised problems that arise in the analysis of single cell RNA sequencing data, where sample splitting does not allow us to avoid double dipping. Unfortunately, in some problems, sample splitting is unattractive or impossible.

RNA 40

RNA 40

The Pharma Data

DECEMBER 10, 2020

1, 2019, until effective screening methods are implemented.”. We know now that the viral RNA is found in stool and infectious virus as well. Therefore, Carlson said, “we advised no use of fecal donations from after Dec. There were no methods for testing for COVID in stool,” he said. “We Infection in the GI tract is likely.”

FDA 52

FDA Laboratories RNA Virus 52

PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. A bioweapon could have been created much faster. of the genome sequence.

Virus 52

Virus RNA DNA Science 52

Drug Target Review

JULY 11, 2024

Ribonucleic acid (RNA) sequencing is an established approach, in which messenger RNA (mRNA) transcripts within the cell are used to produce a readout of the proteins they code for on the cell surface. Roman also serves as the Director of the Department of Translational Genomics and as Professor at the University of Cologne.

Therapies 56

Therapies RNA Pharma Companies Disease 56

The Pharma Data

JANUARY 21, 2021

In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 copies per milliliter [c/mL] at Week 48), with a comparable number of patients receiving either CABENUVA or their daily current antiretroviral regimen (CAR) having an HIV-1 RNA level ?50

FDA Approval 52

FDA Approval Treatment RNA FDA 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death.

Science 124

Science Medical Schools Disease Hospitals 124

Broad Institute

OCTOBER 24, 2023

DCD-FG uses a Gaussian non-linear low-rank structural equation model and shows significant improvements compared to state-of-the-art methods in both simulations as well as a recent large-scale single-cell RNA sequencing data set with hundreds of genetic interventions.

RNA 40

RNA Research 40

The Pharma Data

MAY 31, 2022

Nasdaq: MRNA) a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, and Takeda ( TSE:4502/NYSE:TAK ) announced to transfer the marketing authorization in Japan for Moderna’s COVID-19 vaccine Spikevax TM (mRNA-1273) from Takeda to Moderna in Japan as of August 1, 2022. Moderna, Inc., About Moderna.

Vaccine 52

Vaccine Marketing RNA Science 52

Drug Target Review

AUGUST 24, 2023

Her discoveries on the first-in-class RNA-based innate immune receptor agonist RGT100, built the foundation for the initiation of a Phase I clinical trial as well as the successful acquisition of Rigontec by MSD (known as Merck & Co. 2019 May 22;10:1078. in North America) in late 2017. Frontiers in Immunology.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

Drug Target Review

SEPTEMBER 25, 2024

Analysis of transcriptional changes using RNA sequencing further confirmed that TT125-802 suppresses key non-oncogene resistance mechanisms including transcriptional networks around stemness, epithelial-mesenchymal transition (EMT), and transforming growth factor beta (TGFβ) signalling. Nature Reviews Drug Discovery [Internet].

Small Molecule 105

Small Molecule Therapies Regulations Treatment 105

New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., In addition, older dogs had bacterial antigens and ribosomal RNA in their brains, consistent with systemic infection seen in humans. 2019 Jan;5(1):eaau3333.

Small Molecule 62

Small Molecule DNA Disease Trials 62

The Pharma Data

SEPTEMBER 9, 2020

Immunization of non-human primates (rhesus macaques) with BNT162b2, a nucleoside-modified messenger RNA (modRNA) candidate that expresses the SARS-CoV-2 spike glycoprotein, resulted in strong anti-viral effects against an infectious SARS-CoV-2 challenge.

Vaccine 52

Vaccine Clinical Trials RNA Trials 52

Drug Target Review

MARCH 6, 2024

LSD1 acts as an epigenetic modifier but also forms a variety of complexes with transcription factors, promoters, activators, corepressors and non-coding RNA. What are the specific mechanisms through which LSD1 inhibition leads to tumour cell death?

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Production Pharmacokinetics Disease RNA 64

The Pharma Data

JULY 6, 2021

Fitusiran is an investigational, subcutaneously administered small interference RNA therapy in development for the treatment of people with hemophilia A or B, with or without inhibitors and has the potential to transform treatment as it would be the only prophylactic therapy with as few as six injections per year. a Sanofi Company.

Therapies 52

Therapies Pharmacokinetics Treatment RNA 52

Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

OCTOBER 21, 2020

While the majority of participants (93%, 1,615) maintained their routine dosing schedule from December 2019 through the analysis end point of September 15, 2020, 129 participants (7%) in the ongoing clinical trials had a planned injection visit that was impacted by COVID-19. Source: GSK . Posted: October 2020.

Clinical Development 52

Clinical Development Therapies Clinical Trials Treatment 52

The Pharma Data

JANUARY 31, 2021

Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. Utilizing Clover’s proprietary Trimer-Tag© technology, S-Trimer is a trimeric SARS-CoV-2 spike (S)-protein subunit vaccine candidate.

Vaccine 52

Vaccine Trials Virus RNA 52

Codon

MARCH 24, 2024

A 2019 report from RethinkX, an independent research group, states that the “cost to produce a single molecule using [precision fermentation] has fallen from $1 million per kilogram in 2000, to about $100 today.” ” Efforts are also underway at Asimov and elsewhere to make cells more efficient units of production.

Engineering 85

Engineering Vaccine Production RNA 85

The Pharma Data

DECEMBER 8, 2020

chief executive officer at Ionis, said, “In 2020, we pursued an aggressive agenda focused on building our commercial plans and capabilities, progressing the Ionis-owned pipeline, advancing our technology and growing our leadership position in RNA-targeted therapeutics. Monia , Ph.D., It is available here for a limited time.

RNA 52

RNA Pharmaceuticals Disease Treatment 52

The Pharma Data

AUGUST 31, 2020

About the cobas HIV-1/HIV-2 Qualitative Test cobas HIV-1/HIV-2 Qualitative for use on the cobas 6800/8800 Systems is an in vitro nucleic acid amplification test for the qualitative detection and differentiation of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) RNA in human serum and plasma. .

FDA Approval 52

FDA Approval FDA Virus Disease 52

Elrig

APRIL 29, 2024

She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Driven by an interest in structural biochemistry and drug discovery (DD), I joined AstraZeneca in 2019.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

PLOS: DNA Science

MARCH 7, 2024

An Alu repeat is a “retrotransposon,” a short sequence of RNA that is copied into DNA that then inserts into the genome. Retrotransposons increase in number over time as DNA copies are peeled off of RNA templates. A report from 2019 listing genes and pathways associated with increased risk of NTDs will have to add TBXT.

DNA 52

DNA RNA Research Science 52