National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

Kendal Chidwick NDARC’s Kendal Chidwick discusses the findings from a recently published study that examined how patterns of opioid agonist treatment medicines have changed over the past decade. In September 2019, a new formulation of long-acting injectable buprenorphine became available on the PBS.

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Drug Discovery World

JULY 2, 2024

Standard care for severe EV-D68 infection or AFM is limited to supportive treatment and treatment for immune disorders, which has not been comprehensively evaluated. EV-D68 is a virus of growing public health concern due to its association with the intermittent AFM outbreaks.

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Drug Target Review

JUNE 9, 2023

This exclusive interview with Dr Sharon Benzeno, Chief Commercial Officer, Immune Medicine at Adaptive Biotechnologies, unveils some ground-breaking research on T- cell therapy for cancer , which has seen the first TCR-based therapeutic candidate progress to clinical development, offering promising advancements in innovative cancer treatments.

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The Pharma Data

DECEMBER 11, 2020

11, 2020 — From 1990 to 2019, there was an increase in the burden of cardiovascular disease (CVD) globally, according to a study published online Dec. The researchers found that prevalent cases of total CVD increased from 271 million in 1990 to 523 million in 2019, and the number of CVD deaths increased from 12.1 FRIDAY, Dec.

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Common Sense for Drug Policy Blog

NOVEMBER 29, 2023

Receipt of Opioid Use Disorder Treatments Prior to Fatal Overdoses and Comparison to No Treatment "The findings revealed that exposures to MOUD, even if not continued throughout the six-month exposure period was associated with reduced risk of a fatal poisoning compared to non-MOUD forms of treatment and no treatment exposure.

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SCIENMAG: Medicine & Health

JUNE 8, 2023

Statement Highlights: A new American Heart Association scientific statement focuses on treatment strategies for pediatric cardiomyopathy (diseases of the heart muscle’s structure and function that may lead to heart failure and death) and is a companion to a 2019 scientific statement focused on diagnosis of the condition.

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The Pharma Data

DECEMBER 22, 2020

22, 2020 — Before the COVID-19 pandemic hit, life expectancy in the United States rose in 2019 for the second year in a row, according to two new federal government reports. That would be a new record and represent 400,000 more deaths than were recorded for 2019. TUESDAY, Dec. history, according to the Associated Press.

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Creative Biolabs

JANUARY 15, 2020

The production of new drugs and biological products means providing patients with new treatment options, which has greatly promoted progress in the field of health care.

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Common Sense for Drug Policy Blog

JUNE 4, 2023

Heroin Treatment in the UK "Heroin Assisted Treatment (HAT) is an alternate treatment modality for people for whom more traditional forms of OST have been ineffective. 2003 ) and strong results from RIOTT indicating improved outcomes for ‘treatment refractory’ people (i.e. 2010 ; van den Brink et al., Moore, H.

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Drug Discovery World

MAY 20, 2024

BenevolentAI’s strategic collaboration with AstraZeneca began in 2019, and originally focused on discovering potential new treatments for idiopathic pulmonary fibrosis (IPF) and chronic kidney disease (CKD). Current heart failure treatments follow a “one-size-fits-all” approach.

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Drug Target Review

JULY 12, 2023

Molecular-level biochemical assays like transcriptomics, genomics and proteomics have emerged as valuable tools for identifying potential targets in cancer treatment through deep cyclic inhibition (DCI). How does the DCI mechanism compare to the design of other drugs for cancer treatment?

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Common Sense for Drug Policy Blog

JUNE 4, 2023

Opioid Substitution Treatment in the UK "Opioid substitution therapy (OST) is an evidence-based treatment for opioid dependency, with treatment engagement shown to be protective against drug related deaths ( Santo et al., 2019 ; Public Health England, 2018 ). dwf_admin Sun, 06/04/2023 - 20:03 Source Poulter, H.

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Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

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Common Sense for Drug Policy Blog

OCTOBER 7, 2023

2019 ; Treloar et al., 2019 ), which likely increases overdose risk more so than infection risk. The increase in risk immediately following prison release may reflect return to injection use, poor access to health and social supports, and material deprivation (poverty and homelessness) ( Binswanger et al., 2012 ; Joudrey et al.,

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The Pharma Data

JUNE 2, 2023

Phase 3 Studies of Pfizer’s Novel Antibiotic Combination Offer New Treatment Hope for Patients with Multidrug-Resistant Infections and Limited Treatment Options Pfizer Inc. No patient treated with ATM-AVI experienced a treatment-related SAE. million deaths globally were caused by bacterial AMR in 2019 alone.

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Drug Discovery World

NOVEMBER 13, 2023

Genome sequencing has been used to study typhoid fever in a study in Zimbabwe and understand how the disease has evolved to be resistant to treatment. In response, an emergency reactive vaccination campaign using Typhoid Conjugate Vaccine (TCV) was initiated in suburbs of Harare in 2019, providing moderate protection. Typhi strains.

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Drug Discovery World

JANUARY 2, 2024

South Korean researchers have found that the use of Janus kinase (JAK) inhibitors as a treatment for atopic dermatitis (AD) is not associated with a greater risk of serious adverse events. They reviewed the available safety data and analysed the risk of 11 adverse events from 14 RCTs published between 2019 and 2022.

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Drug Discovery World

OCTOBER 16, 2023

University College London (UCL) spinout AstronauTx has closed a £48m ($61m) Series A financing to develop novel treatments for Alzheimer’s disease and other neurodegenerative disorders. The company was launched in 2019, initially to build on research from the Alzheimer’s Research UK UCL Drug Discovery Institute (UCL DDI).

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Drug Discovery World

JULY 1, 2024

million people died from CVDs in 2019, representing 32% of all global deaths 1. The World Health Organization (WHO) reports that cardiovascular diseases (CVDs) are the leading cause of death globally, stating that an estimated 17.9 Following its inception, the Novo Nordisk Foundation awarded a grant of DKK 150 million ($21.46

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Drug Discovery World

JULY 15, 2022

Pharmaceutical company Transpire Bio will work alongside drug delivery provider Recipharm to develop two inhaled medicines for the treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD).? . Asthma is thought to affect over 300 million people and in 2019 caused 455,000 deaths 1. million people dying from the condition.

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Drug Discovery World

NOVEMBER 17, 2022

In 2019, it was estimated that 1.2 In England, during 2019/20, there were over 90,000 hospital admissions – yet the global pipeline for new antibiotics to address this growing problem has been failing. . million deaths globally, were due to antibiotic-resistant infections.

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Drug Discovery World

APRIL 29, 2024

To investigate the effects of aspirin (a nonsteroidal anti-inflammatory drug) on colorectal cancer, investigators in Italy obtained tissue samples from 238 patients who underwent surgery for colorectal cancer in 2015–2019, 12% of whom were aspirin users.

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Drug Discovery World

MARCH 28, 2024

Teva was ruled in breach of several clauses of the 2019 Code for failing to include the black triangle for Ajovy in an article which, in the Panel’s view, Teva was responsible for and was promotional.

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BioPharma Drive: Drug Pricing

AUGUST 28, 2023

The treatment, developed by a biotech Bayer acquired in 2019, appeared safe in a small trial and showed signs of an effect on disease progression.

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Common Sense for Drug Policy Blog

MAY 8, 2024

People Incarcerated in US Jails Receiving Medication for Opioid Use Disorder "At midyear 2019, the highest percentage of confined persons receiving MAT was reported in jails in the Northeast (3%), followed by jails in the Midwest and West (1% each) and jails in the South (0.4%) (table 7). or more per 100,000 U.S. Maruschak, Todd D.

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Drug Discovery World

AUGUST 23, 2022

A Phase I/II clinical trial targeting a treatment for Huntington’s Disease (HD) using a gene therapy has been given the clearance to go ahead in France. . In 2019, BV-101 was granted orphan drug designation in the European Union. . There are currently no approved disease modifying therapies for Huntington’s Disease.

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Drug Discovery World

JULY 28, 2023

million deaths globally in 2019 were directly attributed to resistant bacteria and a further 4.9 It means the pharmaceutical company is less interested in sales volume and more likely to invest in developing novel treatments. We’re still not where we need to be given the urgency of the situation.” million deaths were associated.

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Drug Discovery World

MARCH 23, 2023

million) Collaborative Discovery Programme for drug discovery innovators to accelerate the development of new treatments for people with CF. Applicants must address patients’ priorities for improving treatment set out in the CF AMR Syndicate’s recently-published ‘Target Product Profiles for Antimicrobials’.

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The Pharma Data

FEBRUARY 8, 2021

Janssen Announces Treatment with ERLEADA ® (apalutamide) Significantly Improved Overall Survival in Patients with Metastatic Castration-Sensitive Prostate Cancer. ERLEADA ® is an androgen receptor (AR) inhibitor indicated for the treatment of patients with nmCRPC and for the treatment of patients with mCSPC. 10 months. [5]

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Drug Discovery World

NOVEMBER 23, 2022

A first-in-class investigational antitubercular agent has shown early bactericidal activity with a low, once-daily oral dose after 14 days of treatment. . The company hopes GSK3036656 could be a component of simpler treatment regimens in the future which could help address the TB epidemic. . In 2019, it was estimated that 1.2

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The Pharma Data

SEPTEMBER 9, 2020

CERENOVUS Launches New Suite of Technologies to Advance Stroke Treatment. CERENOVUS Launches New Suite of Technologies to Advance Stroke Treatment. CERENOVUS offers a broad portfolio of devices used in the endovascular treatment of hemorrhagic and ischemic stroke. Stroke Research and Treatment, Hindawi, 27 Nov.

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Drug Discovery World

OCTOBER 17, 2023

Among 59 treatment-naïve patients, ORR was 75%; median DoR was not estimable (NE). The PHAROS trial demonstrated that these patients could benefit from Braftovi + Mektovi targeted therapy regardless of their prior treatment history.” The major efficacy outcome measures were objective response rate (ORR) per RECIST v1.1

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The Pharma Data

FEBRUARY 22, 2021

Efanesoctocog alfa, a novel and investigational factor VIII therapy independent of von Willebrand Factor, is designed to provide near-normal factor activity levels for the majority of the week in a once-weekly prophylactic treatment regimen. In 2019, Sobi’s revenues amounted to SEK 14.2

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Drug Discovery World

NOVEMBER 9, 2022

Patients can now access SZC in the emergency care setting for the treatment of acute, life-threatening hyperkalaemia alongside standard care. . In July 2019, the National Institute for Health and Care Excellence (NICE) for England, Wales, and Northern Ireland issued a positive recommendation for SZC in the emergency care setting. .

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Drug Discovery World

NOVEMBER 1, 2022

Its snapshot report aimed to provide both an overview of the sector in Australia to determine how the sector has changed since this data was collected in 2017 and 2019 2. . The number of employees behind our biotech companies has also expanded, increasing 21% compared with 2019 from approximately 87,397 people in 2019 to 105,569 in 2022.

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The Pharma Data

JANUARY 17, 2021

This coverage provides a minimally invasive treatment alternative for eligible patients. “Not being able to breathe really limits the ability of patients to go about their daily lives, and for those who qualify for the treatment, endobronchial valves can make a big difference.” 1354-1362, 2019.

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Drug Discovery Today

DECEMBER 17, 2019

December 10, 2019 — Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, today announced that it has completed clinical production of Bridge Therapeutics Inc.’s Somerset, N.J. Birmingham, Ala.–

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