Broad Institute

AUGUST 31, 2023

Prime editing can make targeted insertions, deletions and other changes to DNA, and was first described in 2019 by the lab of David Liu , core institute member, Richard Merkin Professor, and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute. “We

DNA 145

DNA RNA Engineering Laboratories 145

Chemical Biology and Drug Design

NOVEMBER 13, 2023

SARS-CoV-2 is responsible for the coronavirus disease of 2019 (COVID-19) which is one of the most widespread and powerful infections affecting human lungs. WHO proclaimed the outbreak of the Ebola virus disease (EVD), in 2014 that killed hundreds of people in West Africa.

Vaccine 100

Vaccine Laboratories RNA Clinical Development 100

Drug Target Review

OCTOBER 26, 2023

1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. It has been well established that exposure to wild-type AAV results in priming of the immune system against the virus. Adeno-associated virus vector as a platform for gene therapy delivery.

Engineering 105

Engineering Virus Therapies Immune Response 105

Drug Target Review

SEPTEMBER 4, 2023

Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. 2019): CRISPR in Parasitology: Not Exactly Cut and Dried! Sebastian, B.,

Drugs 111

Drugs RNA DNA Disease 111

Broad Institute

JULY 19, 2023

Previous methods introduce millions of AAV capsids — the outer shells of the virus that bind to target proteins — into animals and rely on iterative rounds of screening to find AAVs that reach specific cells. Scientists have engineered adeno-associated viruses (AAVs) to package and deliver gene therapies to cells in the body.

Therapies 98

Therapies Research Engineering Virus 98

The Pharma Data

APRIL 25, 2021

Nirsevimab demonstrate d protect ion against respiratory syncytial virus disease in healthy infants in Phase 3 trial. Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in all infants. 1 – 5. RSV is the most common cause of LRTI and the leading cause of hospitalizations in all infants.

Virus 40

Virus Trials Disease Hospitals 40

Broad Institute

JANUARY 30, 2024

He has also emerged in recent years as a skilled and relatable science communicator, renowned for his efforts at Broad and beyond during the COVID-19 pandemic to unpack the fast-moving research on the new virus in an accessible way and give practical advice about masking, vaccines, and other public health measures.

Hospitals 137

Hospitals Virus Medical Schools Science 137

The Pharma Data

NOVEMBER 20, 2020

It found that about 14% (34 million) of adults smoked cigarettes in 2019, the same rate as in 2017 and 2018. About 4.5% (11 million) of adults were current e-cigarette users in 2019, compared with 3.2% The rate was 16% in 2016, the Associated Press reported. in 2018 and 2.8%

Virus 52

Virus Disease 52

Drug Target Review

JANUARY 3, 2024

He continued that their findings indicate that trapping virus particles in an elevated, unstable state disassembles the particles, which kills the virus and effectively stops infection. This is because this blocks the transmission chain, preventing the virus from spreading from cell to cell. Viruses in the GII.4 4 norovirus.

Virus 64

Virus Immune Response Vaccine Disease 64

The Pharma Data

NOVEMBER 13, 2020

13, 2020 — Measles cases reached their highest number in 23 years in 2019, according to research from the World Health Organization and U.S. In 2019, there were 869,770 cases, the highest number reported since 1996, and global measles deaths increased 50 percent since 2016 to an estimated 207,500 in 2019. FRIDAY, Nov.

Vaccine 52

Vaccine Virus Disease Research 52

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. An altered virus could have escaped. Evidence that the virus emerged, or escaped, from the wildlife trade is lacking. Her points: 1. Coincidence? I’ve never thought so. RaTG13 shares about 96.1%

Virus 52

Virus RNA DNA Science 52

The Pharma Data

JANUARY 11, 2021

China’s National Health Commission said the WHO team will meet with Chinese counterparts, but it was not clear if they will go to the city of Wuhan, where the new coronavirus was first detected in late 2019, the Associated Press reported. ” Associated Press Article. © 2021 HealthDay. ” Associated Press Article.

Virus 52

Virus Government Marketing Research 52

The Pharma Data

JANUARY 27, 2021

million deaths attributed to cardiovascular disease (CVD) globally in 2019, according to a report from the American Heart Association published online Jan. According to the report, in 2019, about 18.6 million cases in 2019, representing a 26.6 WEDNESDAY, Jan. 27 in Circulation. Virani, M.D., Virani, M.D., percent from 2010.

Disease 52

Disease Virus Pharmaceuticals 52

Quanticate

JUNE 16, 2020

The leading cause of death in patients with coronavirus disease 2019 (COVID-19), caused by the virus ‘severe acute respiratory syndrome coronavirus 2’ (SARS‑CoV‑2), is respiratory failure from acute respiratory distress syndrome. [1]

Clinical Trials 52

Clinical Trials Trials Virus Disease 52

The Pharma Data

SEPTEMBER 28, 2020

The UK’s first hospital trust to record 1,000 Covid-19 deaths says the toll is the “terrible reality” of the virus. The most recent inspection report, published by the Care Quality Commission in February 2019, rated the trust as good. Coronavirus pandemic. image copyright EPA. per 100,000 people.

Hospitals 52

Hospitals Virus 52

The Pharma Data

FEBRUARY 1, 2021

They spent about an hour at the Huanan Seafood Market, which was the site of an outbreak of the virus in December 2019, the Associated Press reported. Initially, experts suspected the new coronavirus came from wild animals sold at the market, but the site has been largely ruled out as a source of the virus.

Vaccine 52

Vaccine Virus Marketing Compliance 52

The Pharma Data

NOVEMBER 13, 2020

The death toll of 207,500 in 2019 was 50% higher than just three years earlier, The New York Times reported. No measles deaths were reported in the United States in 2019, but the country had the highest number of cases since 1992. Centers for Disease Control and Prevention analysis finds.

Vaccine 52

Vaccine Virus Disease Trials 52

The Pharma Data

OCTOBER 19, 2020

New Guidance: The FDA issued and implemented new guidance, Enforcement Policy for Modifications to FDA-Cleared Molecular Influenza and RSV Tests During the Coronavirus Disease 2019 (COVID-19) Public Health Emergency. The assay targets on coronavirus-specific nanobodies and tests affinity and efficacy to prevent the virus infection. .

Vaccine 52

Vaccine Virus FDA Clinical Trials 52

Codon

OCTOBER 13, 2024

Through genetic engineering, researchers have developed Golden Rice which can help address the problem of vitamin A deficiency , cotton that produces its own insecticide , virus-resistant papayas , and more. Yields were devastated. These ringspot-resistant papayas entered production in 1998 and resuscitated the industry.

Engineering 96

Engineering Virus Production DNA 96

The Pharma Data

FEBRUARY 1, 2021

They spent about an hour at the Huanan Seafood Market, which was the site of an outbreak of the virus in December 2019, the Associated Press reported. Initially, experts suspected the new coronavirus came from wild animals sold at the market, but the site has been largely ruled out as a source of the virus.

Marketing 40

Marketing Virus Government International 40

The Pharma Data

OCTOBER 28, 2020

In the overall patient group with detectable virus at baseline, the average daily reduction in viral load through day 7 was a 0.36 About REGN-COV2 REGN-COV2 is a combination of two monoclonal antibodies (REGN10933 and REGN10987) and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19.

Virus 40

Virus Trials Clinical Trials Production 40

NIH Director's Blog: Drug Development

JUNE 30, 2020

It’s now clear that nearly everyone who recovers from coronavirus disease 2019 (COVID-19) produces antibodies that specifically target SARS-CoV-2, the novel coronavirus that causes the infection. In the Nussenzweig lab, the team has spent years searching for broadly neutralizing antibodies against the human immunodeficiency virus (HIV ).

Immune Response 52

Immune Response Virus Vaccine Research 52

PerkinElmer

FEBRUARY 28, 2022

In early 2019, no one could have predicted that a novel coronavirus would sweep around the globe and cause one of the most significant health crises of recent times. Fast-forward to today, and thousands of scientists have turned their attention to studying SARS-CoV-2, the virus responsible for the current COVID-19 pandemic.

Virus 52

Virus Vaccine Clinical Trials Treatment 52

The Pharma Data

DECEMBER 2, 2020

STRASBOURG, France–( BUSINESS WIRE )– Regulatory News: Transgene SA (Paris:TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, announced that the Board, at its meeting today, approved the appointment of Hedi Ben Brahim as the Company’s new Chairman and CEO, effective January 1 st , 2021.

Virus 52

Virus Vaccine Treatment Therapies 52

The Pharma Data

MARCH 24, 2021

Strong R&D commitment to developing therapeutics against SARS-CoV-2 virus. billion EUR (2019: 3.78 billion EUR (2019: 2.72 billion EUR (2019: 3.34 At the end of 2020, the equity ratio stood at 47% (2019: 44%). At the end of 2020, the equity ratio stood at 47% (2019: 44%). “We billion EUR (2019: 1.07

Therapies 52

Therapies Disease Vaccine Small Molecule 52

The Pharma Data

AUGUST 16, 2021

Still, with the continuing threat of the Delta variant and possible emergence of other variants in the future, we must remain vigilant against this highly contagious virus,” said Albert Bourla, Chairman and Chief Executive Officer, Pfizer. We continuously strive to stay at least one step ahead of the virus.

Vaccine 52

Vaccine FDA Virus Immune Response 52

The Pharma Data

JANUARY 26, 2021

offered its genomics expertise to identify emerging variants of the SARS-CoV-2 virus to countries that lack the resources to make such identifications. The plan dovetails with the Chatham House Sustainable Laboratories Initiative , announced in 2019. On Tuesday, the U.K. The offer came as part of the U.K.’s South Africa and Brazil.

Virus 52

Virus Vaccine Laboratories International 52

The Pharma Data

OCTOBER 23, 2020

In the past 20 years, countries have invested heavily in preparing for terrorist attacks, but relatively little in preparing for the attack of a virus – which, as the COVID-19 pandemic has proven, can be far more deadly, disruptive and costly.” . Delivering Universal Health Coverage 2030 was launched in 2019. . .

Virus 52

Virus Government 52

Codon

FEBRUARY 27, 2024

Patient YY’s neighbors quickly started to become infected, passing on the virus in turn. While the consensus that emerged among experts was that the virus spread primarily via airborne transmission , it also made use of another route: fomite transmission. million people in 2019. 1 Subscribe to receive Asimov Press essays.

Virus 69

Virus Hospitals Production Regulations 69

The Pharma Data

DECEMBER 10, 2020

1, 2019, until effective screening methods are implemented.”. We know now that the viral RNA is found in stool and infectious virus as well. Therefore, Carlson said, “we advised no use of fecal donations from after Dec. There were no methods for testing for COVID in stool,” he said. “We Infection in the GI tract is likely.”

FDA 52

FDA Laboratories RNA Virus 52

Codon

DECEMBER 12, 2024

This includes recipients of a three-million-dollar grant , awarded by the National Science Foundation in 2019, to “design, construct, and safely deploy synthetic mirror cells.” For a 2019 paper , researchers synthesized an entire, natural-chirality bacterial genome, stretching about 4 million base pairs in length.

RNA 102

RNA DNA Vaccine Virus 102

The Pharma Data

FEBRUARY 24, 2022

Medicago, a biopharmaceutical company headquartered in Quebec City, and GlaxoSmithKline (GSK) today announced that Health Canada has granted approval for COVIFENZ®, COVID-19 vaccine, (plant-based virus-like particles [VLP], recombinant, adjuvanted). This vaccine is indicated for active immunization to prevent coronavirus disease 2019 (COVID?19)

Vaccine 52

Vaccine Virus Government Disease 52

The Pharma Data

DECEMBER 4, 2020

5 to May 23 in three separate years: 2018, 2019 and 2020. They found that the percent of total emergency visits due to asthma was lower in 2020 than in 2018 and 2019. But in the first post-shutdown week, emergency visits dropped 80% and 82% compared to those weeks in 2018 and 2019. In the new study, published online Dec.

Hospitals 52

Hospitals Doctors Virus Treatment 52

The Pharma Data

AUGUST 18, 2020

REGN-COV2 could provide a much-needed treatment option for people already experiencing symptoms of COVID-19, and also has the potential to prevent infection in people exposed to the virus, thus slowing the spread of the global pandemic. and Roche will be responsible for distribution outside the U.S. “We

Clinical Trials 52

Clinical Trials Virus Trials Treatment 52

PLOS: DNA Science

OCTOBER 12, 2023

Consider Zolgensma , a gene therapy approved in 2019 to treat spinal muscular atrophy. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Can they deliver healing genes without triggering an overactive immune response?

Therapies 69

Therapies Immune Response DNA Virus 69

The Pharma Data

JANUARY 11, 2021

Pfizer and BioNTech reported that their COVID-19 vaccine appears to be effective against a key mutation in new variants of the SARS-CoV-2 virus that causes COVID-19. SARS-CoV-2, the virus that causes COVID-19, has mutated into several strains. A study published by the U.S. The plan is to produce 2 billion doses this year. .

Vaccine 52

Vaccine Clinical Trials Immune Response Trials 52

The Pharma Data

JANUARY 29, 2021

Seroconversion to SARS-CoV-2 and OHSD in 2019 were independent predictors for OHSD during the first surge of the epidemic in NYC. “It remains to be seen whether this is due to cardiac complications related to the virus or poor access to health care in neighborhoods that suffered the most during the first wave of the COVID-19 pandemic.”

Hospitals 52

Hospitals Virus Research 52