Drug Target Review

APRIL 7, 2025

As biomarkers become increasingly relevant in indicating the workings and effects of novel therapies, their potential as valuable clinical and regulatory endpoints is also gaining recognition. Biomarkers can play a crucial role throughout clinical development, especially in early phases. Clinical Pharmacology and Therapeutics.

Clinical Development 69

Clinical Development Clinical Trials Clinical Pharmacology Trials 69

The Pharma Data

DECEMBER 17, 2020

The trial remains on-track to complete enrollment of all 500 patients in the United States and Australia before the end of 2020, despite the worsening of the COVID-19 pandemic. In its Phase II clinical trial, TLC599 significantly reduced pain at and through every scheduled visit through six months. SOUTH SAN FRANCISCO, Calif.

Clinical Trials 40

Clinical Trials Trials Pharmaceutical Companies Clinical Pharmacology 40

Drug Target Review

MAY 7, 2024

In 2020, 78 percent of orphan drugs and biologics approved were targeted therapies. At Debiopharm, he has overseen both preclinical and clinical pharmacology of assets from phase I to III.

Disease 59

Disease Clinical Trials Clinical Pharmacology Trials 59

The Pharma Data

MAY 2, 2022

Data from the completed studies of zuranolone in the LANDSCAPE and NEST clinical development programs, including data from the ongoing open-label SHORELINE Study in MDD, as well as data from the completed clinical pharmacology studies, will comprise the full submission package. Food & Drug Administration.

Treatment 52

Treatment Drugs Clinical Pharmacology Clinical Development 52

The Pharma Data

NOVEMBER 8, 2020

9, 2020 00:00 UTC. HK) (“Pharmaron”), a fully integrated contract research and manufacturing organization offering laboratory, CMC and clinical development services for the life science industry, announced today that it has acquired 100% of the equity of Absorption Systems for up to US$137.5 Limited (Stock Code: 300759.SZ/3759.HK)

Clinical Pharmacology 40

Clinical Pharmacology Laboratories Science Pharmaceuticals 40

Metabolite Tales Blog

JULY 5, 2023

With metabolic stability in mind, we take a look at the metabolism of some FDA approved synthetic macrocyclic drugs, and a few of those that were/are in clinical development where metabolism data was available. link] [13] A user’s guide to lorlatinib. Nagasaka et al., Critical Reviews in Oncology/Hematology, 151, 102969, [link]. [16]

Drugs 52

Drugs Metabolic Stability FDA Approval Treatment 52

Metabolite Tales Blog

JULY 5, 2023

With metabolic stability in mind, we take a look at the metabolism of some FDA approved synthetic macrocyclic drugs, and a few of those that were/are in clinical development where metabolism data was available. link] [13] A user’s guide to lorlatinib. Nagasaka et al., Critical Reviews in Oncology/Hematology, 151, 102969, [link]. [16]

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52