The Pharma Data

OCTOBER 14, 2020

15, 2020 (GLOBE NEWSWIRE) — Eloxx Pharmaceuticals, Inc. Conference Call Information : Date : Thursday, November 5, 2020. Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA. WALTHAM, Mass., Time : 4:30 p.m. Domestic Dial-in Number : (866) 913-8546. Eloxx Pharmaceuticals, Inc.

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Codon

AUGUST 26, 2024

Remdesivir, a decade-old broad-spectrum antiviral developed by Gilead and previously tested against Ebola, was quickly approved for emergency use against COVID-19 in May 2020, seven months earlier than the first mRNA vaccines. In fact, the innate immune system uses double-stranded RNA as a key signal that an infection is underway.

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Broad Institute

AUGUST 31, 2023

Our results show that GRouNdGAN is a stable, realistic, and effective simulator with various applications in single-cell RNA-seq analysis.

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Drug Target Review

APRIL 7, 2025

Haemoglobin A1c (HbA1c) is a validated surrogate endpoint for the reduction of microvascular complications associated with diabetes mellitus; reduced HIV-RNA levels serve as an endpoint for HIV disease control; and a reduction in low-density lipoprotein (LDL) cholesterol is used as an endpoint indicating lower likelihood of cardiovascular events.

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New Drug Approvals

SEPTEMBER 23, 2024

Target: DNA/RNA Synthesis Pathway: Cell Cycle/DNA Damage Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder of the brain, having symptoms characterized by involuntary movements, cognitive impairment, and mental deterioration. 2020-01-02. 2020-01-02. SCHEME PATENT PTC Therapeutics Inc.,

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The Pharma Data

DECEMBER 31, 2020

Monthly News Roundup – December 2020. The messenger RNA (mRNA) vaccines encode a form of the spike (S) protein of SARS-CoV-2 virus. Posted: December 2020. Professional. Moderna and Pfizer’s COVID-19 Vaccines Roll Out in Early Phase. In December, the U.S. How do they work? How do they work?

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The Pharma Data

OCTOBER 25, 2020

The messenger RNA-based vaccine, which is designed to block replication of the coronavirus, was shown to induce neutralizing antibodies and activate T-cells in hamsters and mice. German drugmaker CureVac said preclinical studies of its COVID-19 vaccine candidate, CVnCoV, showed the vaccination prompted a successful immune response.

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Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

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The Pharma Data

DECEMBER 10, 2020

We know now that the viral RNA is found in stool and infectious virus as well. Therefore, Carlson said, “we advised no use of fecal donations from after Dec. 1, 2019, until effective screening methods are implemented.”. There were no methods for testing for COVID in stool,” he said. “We Infection in the GI tract is likely.”

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PLOS: DNA Science

MAY 16, 2024

A few days after New Years, 2020, I heard BBC News report the first cases, in China. Whenever and wherever the virus emerged, CDC officially alerted clinicians to the new, deadly respiratory illness on January 8, 2020. After sequencing, artificial intelligence adds context to RNA and DNA sequences through comparisons to others.

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Broad Institute

JUNE 14, 2024

These CRISPR guides are short sequences of RNA that steer the CRISPR Cas9 enzyme to a specific site in the genome to cut DNA and deactivate a targeted gene. The new findings, from scientists at the Broad Institute of MIT and Harvard, show about 2 percent of these guides miss their target.

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The Pharma Data

DECEMBER 14, 2020

Supported by promising phase 1 data, CureVac announced Monday that it has enrolled the first participant in the pivotal phase 2b/3 study of its messenger-RNA based coronavirus vaccine, CVnCoV.

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Drug Target Review

AUGUST 9, 2023

14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts. Many potential toxic effects have been suggested, including the mis-splicing of the Stathmin-2 RNA transcript. 2020, [link] Liscic, Rajka Maria, et al. 1, 1 June 2020, [link] Ling, Shuo-Chien et al.

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The Pharma Data

DECEMBER 27, 2020

In 2020, messenger RNA (mRNA), the technology behind Pfizer’s and Moderna’s COVID-19 vaccine, practically became a household word. Now the gate is open for more mRNA vaccines to flood the space. Source link.

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The Pharma Data

OCTOBER 23, 2020

23, 2020 — In a Society for Healthcare Epidemiology of America white paper, published online Oct. The authors recommended viral load thresholds of 1,000 IU for hepatitis B virus (HBV), hepatitis C virus (HCV) RNA undetectable for HCV, and suppressed viral RNA for HIV for determining any restrictions on HCP practice.

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The Pharma Data

JANUARY 10, 2021

LUXEMBOURG–( BUSINESS WIRE )– Eurofins GeneScan Technologies (Paris:ERF) announces that the VIR Seek SARS-CoV-2 Solution has been evaluated and approved by the AOAC Performance Tested Methods SM (PTM) Program on December 29, 2020 and awarded Emergency Response Validation PTM certification number 122006.

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RNA Virus Research 52

The Pharma Data

OCTOBER 27, 2020

VANCOUVER, BC / ACCESSWIRE / October 28, 2020 / XPhyto Therapeutics Corp. “Applying 3a’s proprietary enhanced RNA technology to PCR testing was a logical next step in our product development pipeline,” said Dr. Heinrich Jehle, managing director of 3a-Diagnostics.

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Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

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The Pharma Data

NOVEMBER 30, 2020

30, 2020 — Multisystem inflammatory syndrome in children (MIS-C) occurs more often among Black and Hispanic children than White children, according to a research letter published online Nov. percent) had detectable severe acute respiratory syndrome coronavirus 2 RNA and/or antibodies. © 2020 HealthDay. Professional.

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The Pharma Data

DECEMBER 28, 2020

28, 2020 — Irinotecan and cetuximab combined with vemurafenib improve progression-free survival in BRAF V600E -mutated colorectal cancer (CRC), according to a study published online Dec. Based on RNA profiling, treatment benefit was not dependent on previously established BRAF subgroups or the consensus molecular subtype.

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The Pharma Data

OCTOBER 21, 2020

22, 2020 (GLOBE NEWSWIRE) — Atea Pharmaceuticals, Inc. , AT-527 is expected to be ideally suited to combat COVID-19 as it inhibits viral replication by interfering with viral RNA polymerase, a key component in the replication machinery of RNA viruses. BOSTON, Oct.

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Drug Target Review

MARCH 21, 2024

Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow. 2020 Jul 3;10(1):10967. AAV-based therapies often can’t be dosed more than once due to concerns about an immune response.

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The Pharma Data

FEBRUARY 22, 2022

State-of-the-art facility will headquarter research efforts in Boston and New York to accelerate the development of RNA and DNA-based medicines.

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The Pharma Data

OCTOBER 19, 2020

20, 2020 12:00 UTC. Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen.

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The Pharma Data

OCTOBER 30, 2020

30, 2020 — Viral load was decreased at day 11 for patients with mild or moderate COVID-19 who received a single intravenous infusion of virus-neutralizing monoclonal antibody versus placebo, according to a study published online Oct. percent of viral RNA at day 11. © 2020 HealthDay. Posted: October 2020.

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The Pharma Data

FEBRUARY 8, 2021

Fitusiran is an investigational, subcutaneously administered small interference RNA therapy in development for the treatment of people with hemophilia A or B, with or without inhibitors.

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Broad Institute

MARCH 5, 2024

In this talk, we are motivated by unsupervised problems that arise in the analysis of single cell RNA sequencing data, where sample splitting does not allow us to avoid double dipping. Unfortunately, in some problems, sample splitting is unattractive or impossible.

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LifeSciVC

DECEMBER 5, 2024

combinatorial chemistry, human genetics, functional genomics, mRNA, I/O, CRISPR, RNA editing, and many others). Other than Flagship’s fund with the monster Moderna position in 2020-2022, I don’t think that’s ever been done before in the history of the biotech industry.

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Broad Institute

JANUARY 30, 2024

RESEARCH, INTERRUPTED When Bhattacharyya first heard rumblings about the new respiratory virus spreading overseas in early 2020, his lab had only one other member, a research assistant. But in April 2020, “suddenly, half the patients at the hospital had a brand new infection, so we were busier than ever by a long shot,” he recalled.

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PerkinElmer

JANUARY 19, 2020

A Novel Deep Learning and Machine Vision System for Automating Blood Fractionation on a High-Throughput Liquid Handling Platform DATE: Tuesday, January 28, 2020 TIME: 2:00 PM – 3:00 PM POSTER: Presentation | Poster Number: 1017-C Author: James Atwood, General Manager Applied Genomics, PerkinElmer, Inc.

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The Pharma Data

SEPTEMBER 9, 2020

Immunization of non-human primates (rhesus macaques) with BNT162b2, a nucleoside-modified messenger RNA (modRNA) candidate that expresses the SARS-CoV-2 spike glycoprotein, resulted in strong anti-viral effects against an infectious SARS-CoV-2 challenge. The information contained in this release is as of September 9, 2020.

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The Pharma Data

NOVEMBER 7, 2020

8, 2020 /PRNewswire/ — Since doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed that a subset of these patients experience a side effect that clinically looks like inflammatory arthritis. NEW YORK , Nov. 4 in rheumatology by U.S.

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The Pharma Data

JANUARY 11, 2021

Moderna is following up on the success of its messenger RNA-based COVID-19 vaccine with plans to develop inoculations for numerous other infectious diseases, the company said Monday. 18, 2020 ). It has also received temporary or conditional authorization in the UK and in the EU ( DID , Jan.

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The Pharma Data

DECEMBER 8, 2020

8, 2020 — AstraZeneca’s COVID-19 vaccine is safe and effective, new data from late-stage trials shows. Both employ a newer technology that uses messenger RNA to prime the immune system to attack the new coronavirus. © 2020 HealthDay. Posted: December 2020. TUESDAY, Dec. New data posted Tuesday on the U.S.

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PLOS: DNA Science

JUNE 13, 2024

The most compelling evidence for the origin lies in the RNA genome sequence similarities between RaTG13 and SARS-CoV-2 – specifically, a part that encodes the “furin binding site” of the spike protein with which the virus adheres to host cells. Whatever the progenitor virus was, its realm extends beyond China.

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Codon

APRIL 8, 2025

The study of RNA tumor viruses revealed reverse transcriptase , an enzyme integral in studying RNA biology. Crucially, this process requires neither DNA nor RNA; proteins alone influence other proteins to change shape. It contained no DNA, no RNA, and no viruses — just a single protein.

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The Pharma Data

JUNE 26, 2021

BioNTech SE (NASDAQ: BNTX, “BioNTech” or “the Company”), announced that the first patient has been treated in its BNT111 Phase 2 cancer vaccine trial (2020-002195-12; NCT04526899). These results were published in Nature in July 2020.

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