The Pharma Data

NOVEMBER 17, 2021

FDA in October 2021. PF-07321332 inhibits viral replication at a stage known as proteolysis, which occurs before viral RNA replication. In preclinical studies, PF-07321332 didn’t demonstrate substantiation of mutagenic DNA relations. Rolling submission ofnon-clinical data for PAXLOVID was initiated with theU.S.

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PLOS: DNA Science

MAY 16, 2024

Had we grown complacent in a world freed from a list of once-deadly infectious diseases, thanks largely to vaccines and other public health measures? Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. Work on vaccines ensued too. COVID clearly caught us off guard.

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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DNA RNA Engineering Vaccine 52

The Pharma Data

JANUARY 13, 2021

13, 2021 — A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts. The new vaccine remains stable for a time in the refrigerator. WEDNESDAY, Jan. 13 in the New England Journal of Medicine.

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The Pharma Data

JANUARY 21, 2021

21, 2021 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 Two percent of patients in both treatment arms had an HIV-1 RNA count ?50

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Codon

MARCH 24, 2024

million liters in 2021, according to an analysis by BioProcess International. Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. The total global bioprocessing capacity was estimated at 17.4 We further estimate that supplying just the U.S.

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Codon

MAY 15, 2023

The paper is also nearly two years old at this point; the preprint was published in August 2021. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. PE-tag is a new method that detects off-target DNA changes during a gene-editing experiment. From Davis J.R.

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DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

The paper is also nearly two years old at this point; the preprint was published in August 2021. 3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. PE-tag is a new method that detects off-target DNA changes during a gene-editing experiment. From Davis J.R.

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DNA Bioinformatics Engineering Virus 52

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. The new sequences might help de-extinction efforts.

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PLOS: DNA Science

MARCH 30, 2023

The agency launched FungiNet in 2021, as “a network for molecular surveillance and genomic epidemiology for fungal diseases,” with initial focus on C. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA).

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PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. The book that kickstarted DNA Science was The Forever Fix: Gene Therapy and the Boy Who Saved It. We renamed it DNA Science. That got me thinking.

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Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

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