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Game-changing pan-TEAD inhibitor for solid tumours

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What are the preclinical characteristics of ISM6331, including its efficacy, safety profile, and drug metabolism and pharmacokinetics (DMPK) properties? The system optimised the molecules that were most likely to succeed in terms of potency, metabolic stability, synthetic accessibility, and more.

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Deuteration at this position was found to block generation of a less selective primary amide metabolite in vivo and increase metabolic stability. Drug metabolism in drug discovery and development. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.

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Game-changing pan-TEAD inhibitor for solid tumours

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